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Trmt12 tRNA methyltransferase 12 [ Mus musculus (house mouse) ]

Gene ID: 68260, updated on 2-Nov-2024

Summary

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Official Symbol
Trmt12provided by MGI
Official Full Name
tRNA methyltransferase 12provided by MGI
Primary source
MGI:MGI:1915510
See related
Ensembl:ENSMUSG00000037085 AllianceGenome:MGI:1915510
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tyw2; 4632406N01Rik
Summary
Predicted to enable tRNA methyltransferase activity. Predicted to be involved in tRNA methylation and wybutosine biosynthetic process. Predicted to be active in cytoplasm. Orthologous to human TRMT12 (tRNA methyltransferase 12 homolog). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human all
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Genomic context

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See Trmt12 in Genome Data Viewer
Location:
15 D1; 15 25.09 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (58744498..58748630)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (58872649..58876781)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41329 Neighboring gene transmembrane protein 65 Neighboring gene STARR-positive B cell enhancer ABC_E5480 Neighboring gene predicted gene, 24041 Neighboring gene STARR-positive B cell enhancer ABC_E3141 Neighboring gene STARR-positive B cell enhancer ABC_E3142 Neighboring gene predicted gene, 36509 Neighboring gene ring finger protein 139 Neighboring gene TatD DNase domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA modification IEA
Inferred from Electronic Annotation
more info
  
involved_in wybutosine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tRNA wybutosine-synthesizing protein 2 homolog
Names
alpha-amino-alpha-carboxypropyl transferase TYW2
tRNA methyltranferase 12 homolog
tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase
tRNA-yW-synthesizing protein 2
NP_080918.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026642.2 → NP_080918.2  tRNA wybutosine-synthesizing protein 2 homolog

    See identical proteins and their annotated locations for NP_080918.2

    Status: VALIDATED

    Source sequence(s)
    AC107772
    Consensus CDS
    CCDS37081.1
    UniProtKB/Swiss-Prot
    Q0P5W5, Q7TNQ8, Q8BG71, Q9D2N1
    Related
    ENSMUSP00000047831.8, ENSMUST00000036937.9
    Conserved Domains (2) summary
    COG0270
    Location:228 → 313
    Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
    pfam02475
    Location:122 → 324
    Met_10; Met-10+ like-protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    58744498..58748630
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BG71.1 GenPept UniProtKB/Swiss-Prot:Q8BG71

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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