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Agpat4 1-acylglycerol-3-phosphate O-acyltransferase 4 [ Mus musculus (house mouse) ]

Gene ID: 68262, updated on 28-Oct-2024

Summary

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Official Symbol
Agpat4provided by MGI
Official Full Name
1-acylglycerol-3-phosphate O-acyltransferase 4provided by MGI
Primary source
MGI:MGI:1915512
See related
Ensembl:ENSMUSG00000023827 AllianceGenome:MGI:1915512
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1500003P24Rik
Summary
Enables 1-acylglycerol-3-phosphate O-acyltransferase activity. Involved in phospholipid metabolic process. Located in endoplasmic reticulum. Is active in mitochondrial outer membrane. Is expressed in several structures, including nervous system; skin; stomach; and testis. Orthologous to human AGPAT4 (1-acylglycerol-3-phosphate O-acyltransferase 4). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in colon adult (RPKM 23.0), lung adult (RPKM 13.9) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Agpat4 in Genome Data Viewer
Location:
17 A1; 17 8.33 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (12337372..12438536)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (12118485..12219649)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene parkin RBR E3 ubiquitin protein ligase Neighboring gene STARR-seq mESC enhancer starr_41839 Neighboring gene DNA segment, Chr 17, ERATO Doi 648, expressed Neighboring gene STARR-seq mESC enhancer starr_41840 Neighboring gene STARR-seq mESC enhancer starr_41841 Neighboring gene predicted gene, 46604 Neighboring gene STARR-seq mESC enhancer starr_41845 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:12311592-12311701 Neighboring gene STARR-seq mESC enhancer starr_41846 Neighboring gene STARR-positive B cell enhancer ABC_E4192 Neighboring gene STARR-seq mESC enhancer starr_41847 Neighboring gene STARR-seq mESC enhancer starr_41848 Neighboring gene VISTA enhancer mm156 Neighboring gene STARR-positive B cell enhancer mm9_chr17:12398581-12398882 Neighboring gene teratocarcinoma-derived growth factor, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_41854 Neighboring gene mitogen-activated protein kinase kinase kinase 4 Neighboring gene predicted gene, 46605 Neighboring gene predicted gene, 24794

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Lpaatδ/Agpat4 deficiency impairs maximal force contractility in soleus and alters fibre type in extensor digitorum longus muscle. Bradley RM, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2018 Jul. PMID 29627383
  2. Agpat4/Lpaatδ deficiency highlights the molecular heterogeneity of epididymal and perirenal white adipose depots. Mardian EB, et al. J Lipid Res, 2017 Oct. PMID 28814640, Free PMC Article
  3. Mice Deficient in lysophosphatidic acid acyltransferase delta (Lpaatδ)/acylglycerophosphate acyltransferase 4 (Agpat4) Have Impaired Learning and Memory. Bradley RM, et al. Mol Cell Biol, 2017 Nov 15. PMID 28807933, Free PMC Article
  4. Data on acylglycerophosphate acyltransferase 4 (AGPAT4) during murine embryogenesis and in embryo-derived cultured primary neurons and glia. Bradley RM, et al. Data Brief, 2016 Mar. PMID 26759825, Free PMC Article
  5. A novel lysophosphatidic acid acyltransferase enzyme (LPAAT4) with a possible role for incorporating docosahexaenoic acid into brain glycerophospholipids. Eto M, et al. Biochem Biophys Res Commun, 2014 Jan 10. PMID 24333445

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study utilizing Lpaat-delta deficient mice identify an important role for murine Lpaat-delta in musculus soleus and extensor digitorum longus contractile force generation.
    Title: Lpaatδ/Agpat4 deficiency impairs maximal force contractility in soleus and alters fibre type in extensor digitorum longus muscle.
  2. Agpat4/Lpaatdelta deficiency highlights the molecular heterogeneity of epididymal and perirenal white adipose depots
    Title: Agpat4/Lpaatδ deficiency highlights the molecular heterogeneity of epididymal and perirenal white adipose depots.
  3. Findings indicate that Lpaatdelta deficiency causes deficits in learning and memory associated with reduced NMDA and AMPA receptors.
    Title: Mice Deficient in lysophosphatidic acid acyltransferase delta (Lpaatδ)/acylglycerophosphate acyltransferase 4 (Agpat4) Have Impaired Learning and Memory.
  4. findings indicate that AGPAT4 is a mitochondrial AGPAT/LPAAT that specifically supports synthesis of brain PI, PC, and PE.
    Title: Acylglycerophosphate acyltransferase 4 (AGPAT4) is a mitochondrial lysophosphatidic acid acyltransferase that regulates brain phosphatidylcholine, phosphatidylethanolamine, and phosphatidylinositol levels.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-acylglycerol-3-phosphate O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-acylglycerol-3-phosphate O-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables lysophosphatidic acid acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in CDP-diacylglycerol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phospholipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
1-acyl-sn-glycerol-3-phosphate acyltransferase delta
Names
1-AGP acyltransferase 4
1-AGPAT 4
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, delta)
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
LPAAT-delta
lysophosphatidic acid acyltransferase-delta
NP_080920.2
XP_006523408.3
XP_006523410.1
XP_006523411.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026644.2 → NP_080920.2  1-acyl-sn-glycerol-3-phosphate acyltransferase delta

    See identical proteins and their annotated locations for NP_080920.2

    Status: PROVISIONAL

    Source sequence(s)
    AK005139
    Consensus CDS
    CCDS28389.1
    UniProtKB/Swiss-Prot
    Q3TKN0, Q8K4X7, Q9DB84
    Related
    ENSMUSP00000024594.3, ENSMUST00000024594.9
    Conserved Domains (1) summary
    PLN02380
    Location:20 → 326
    PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    12337372..12438536
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523347.3 → XP_006523410.1  1-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X2

    See identical proteins and their annotated locations for XP_006523410.1

    Conserved Domains (2) summary
    cd07990
    Location:11 → 150
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:136 → 208
    Acyltransf_C; Acyltransferase C-terminus

  2. XM_006523345.3 → XP_006523408.3  1-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X1

    Conserved Domains (1) summary
    PLN02380
    Location:100 → 406
    PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase

  3. XM_006523348.5 → XP_006523411.1  1-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X2

    See identical proteins and their annotated locations for XP_006523411.1

    Conserved Domains (2) summary
    cd07990
    Location:11 → 150
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:136 → 208
    Acyltransf_C; Acyltransferase C-terminus
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K4X7.1 GenPept UniProtKB/Swiss-Prot:Q8K4X7

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