Hsd3b3 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hsd3b3provided by RGD
Official Full Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3provided by RGD
Primary source: RGD:1592771
See related: EnsemblRapid:ENSRNOG00000080702 AllianceGenome:RGD:1592771
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hsd3b
Summary: Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in C21-steroid hormone metabolic process and steroid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane and mitochondrial membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in hypertension and hypospadias. Orthologous to human HSD3B1 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1) and HSD3B2 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 31706.7) See more
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 2q34

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (188826756..188832734, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (186138044..186144024, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (200756557..200762492, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Letrozole-induced polycystic ovaries showed increased 3beta-HSD expression.
Title: Disruption in the expression and immunolocalisation of steroid receptors and steroidogenic enzymes in letrozole-induced polycystic ovaries in rat.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

RH139877 (e-PCR)
- UniSTS:221961

RH128688 (e-PCR)
- UniSTS:211996

Hsd3b1 (e-PCR), detects polymorphism
- UniSTS:257099

Hsd3b2 (e-PCR), detects polymorphism
- UniSTS:256372

UniSTS:256890 (e-PCR)
- UniSTS:256890

Hsd3b1 (e-PCR), detects polymorphism
- UniSTS:256890

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info
enables steroid delta-isomerase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in C21-steroid hormone metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in steroid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in steroid biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2

Names: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II; 3 beta-hydroxysteroid dehydrogenase/delta-5-delta-4 isomerase type 3; 3 beta-hydroxysteroid dehydrogenase/delta-5-delta-4 isomerase type II; 3-beta-HSD II

NP_001036084.1

EC 1.1.1.145

EC 5.3.3.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001042619.1 → NP_001036084.1 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2

See identical proteins and their annotated locations for NP_001036084.1

Status: PROVISIONAL

Source sequence(s)

M38179

UniProtKB/Swiss-Prot

P22072

UniProtKB/TrEMBL

A0A8I6AMF0, A6K3E1

Related

ENSRNOP00000075324.3, ENSRNOT00000086835.3

Conserved Domains (2) summary

pfam01073
Location:7 → 287

3Beta_HSD; 3-beta hydroxysteroid dehydrogenase/isomerase family

cl21454
Location:5 → 357

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins