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Pja1 praja ring finger ubiquitin ligase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 683077, updated on 2-Nov-2024

Summary

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Official Symbol
Pja1provided by RGD
Official Full Name
praja ring finger ubiquitin ligase 1provided by RGD
Primary source
RGD:1591532
See related
EnsemblRapid:ENSRNOG00000047339 AllianceGenome:RGD:1591532
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to act upstream of or within protein catabolic process. Predicted to be located in cytoplasm. Orthologous to human PJA1 (praja ring finger ubiquitin ligase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 603.5), Kidney (RPKM 318.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pja1 in Genome Data Viewer
Location:
Xq22
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (68621101..68626001, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (64580938..64585846, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (69213645..69218601, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene microRNA 3573 Neighboring gene ephrin B1 Neighboring gene ribosomal protein L27 like 1 Neighboring gene uncharacterized LOC120099284 Neighboring gene proliferating cell nuclear antigen, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Praja1 RING-finger E3 ubiquitin ligase suppresses neuronal cytoplasmic TDP-43 aggregate formation. Watabe K, et al. Neuropathology, 2020 Dec. PMID 32686212, Free PMC Article
  2. A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1. Sasaki A, et al. J Biol Chem, 2002 Jun 21. PMID 11959851
  3. Praja1, a novel gene encoding a RING-H2 motif in mouse development. Mishra L, et al. Oncogene, 1997 Nov 6. PMID 9393880
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Praja1 RING-finger E3 ubiquitin ligase suppresses neuronal cytoplasmic TDP-43 aggregate formation.
    Title: Praja1 RING-finger E3 ubiquitin ligase suppresses neuronal cytoplasmic TDP-43 aggregate formation.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase Praja-1
Names
praja ring finger 1, E3 ubiquitin protein ligase
NP_001094476.1
NP_001385652.1
NP_001385653.1
XP_006257169.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001101006.2 → NP_001094476.1  E3 ubiquitin-protein ligase Praja-1 isoform 1

    See identical proteins and their annotated locations for NP_001094476.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    M0RCT9, Q66HF7
    Related
    ENSRNOP00000067423.2, ENSRNOT00000074071.4
    Conserved Domains (2) summary
    pfam13639
    Location:358 → 399
    zf-RING_2; Ring finger domain
    cl17018
    Location:325 → 358
    FANC; Fanconi anemia ID complex proteins FANCI and FANCD2

  2. NM_001398723.1 → NP_001385652.1  E3 ubiquitin-protein ligase Praja-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    A6IQ68
    Conserved Domains (1) summary
    cd16465
    Location:537 → 582
    RING-H2_PJA1_2; RING finger, H2 subclass, found in protein E3 ubiquitin-protein ligase Praja-1, Praja-2, and similar proteins

  3. NM_001398724.1 → NP_001385653.1  E3 ubiquitin-protein ligase Praja-1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    A0A8I6AEG5
    Related
    ENSRNOP00000111059.1, ENSRNOT00000144187.1
    Conserved Domains (1) summary
    cd16465
    Location:574 → 619
    RING-H2_PJA1_2; RING finger, H2 subclass, found in protein E3 ubiquitin-protein ligase Praja-1, Praja-2, and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    68621101..68626001 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006257107.5 → XP_006257169.1  E3 ubiquitin-protein ligase Praja-1 isoform X1

    UniProtKB/TrEMBL
    M0RCT9
    Conserved Domains (2) summary
    pfam13639
    Location:395 → 436
    zf-RING_2; Ring finger domain
    cl17018
    Location:362 → 395
    FANC; Fanconi anemia ID complex proteins FANCI and FANCD2
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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