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Apoo apolipoprotein O [ Mus musculus (house mouse) ]

Gene ID: 68316, updated on 2-Nov-2024

Summary

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Official Symbol
Apooprovided by MGI
Official Full Name
apolipoprotein Oprovided by MGI
Primary source
MGI:MGI:1915566
See related
Ensembl:ENSMUSG00000079508 AllianceGenome:MGI:1915566
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Micos26; 0610008C08Rik; 1110019O03Rik
Summary
Predicted to be involved in cristae formation. Located in mitochondrion. Is expressed in adrenal gland; liver left lobe; and liver right lobe. Orthologous to human APOO (apolipoprotein O). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in heart adult (RPKM 13.3), kidney adult (RPKM 6.6) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Apoo in Genome Data Viewer
Location:
X C3; X 41.56 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (93410615..93460699)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (94367010..94417093)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene cell division cycle associated 5 pseudogene Neighboring gene family with sequence similarity 90, member A1B Neighboring gene STARR-positive B cell enhancer ABC_E11051 Neighboring gene M phase phosphoprotein 6 pseudogene Neighboring gene predicted gene 14827 Neighboring gene thrombospondin, type I, domain containing 7B pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Overexpression of apolipoprotein O does not impact on plasma HDL levels or functionality in human apolipoprotein A-I transgenic mice. Nijstad N, et al. Biochim Biophys Acta, 2011 Apr. PMID 21296681
  2. Apolipoprotein O expression in mouse liver enhances hepatic lipid accumulation by impairing mitochondrial function. Tian F, et al. Biochem Biophys Res Commun, 2017 Sep 9. PMID 28647361
  3. ApoO, a novel apolipoprotein, is an original glycoprotein up-regulated by diabetes in human heart. Lamant M, et al. J Biol Chem, 2006 Nov 24. PMID 16956892
  4. Loss of APOO (MIC26) aggravates obesity-related whitening of brown adipose tissue via PPARα-mediated functional interplay between mitochondria and peroxisomes. Guo X, et al. Metabolism, 2023 Jul. PMID 37088120
  5. MicroRNA-200c coordinates HNF1 homeobox B and apolipoprotein O functions to modulate lipid homeostasis in alcoholic fatty liver disease. Mostofa MG, et al. J Biol Chem, 2022 Jun. PMID 35460694, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Apolipoprotein O modulates cholesterol metabolism via NRF2/CYB5R3 independent of LDL receptor.
    Title: Apolipoprotein O modulates cholesterol metabolism via NRF2/CYB5R3 independent of LDL receptor.
  2. Macrophage-specific deletion of MIC26 (APOO) mitigates advanced atherosclerosis by increasing efferocytosis.
    Title: Macrophage-specific deletion of MIC26 (APOO) mitigates advanced atherosclerosis by increasing efferocytosis.
  3. Loss of APOO (MIC26) aggravates obesity-related whitening of brown adipose tissue via PPARalpha-mediated functional interplay between mitochondria and peroxisomes.
    Title: Loss of APOO (MIC26) aggravates obesity-related whitening of brown adipose tissue via PPARα-mediated functional interplay between mitochondria and peroxisomes.
  4. MicroRNA-200c coordinates HNF1 homeobox B and apolipoprotein O functions to modulate lipid homeostasis in alcoholic fatty liver disease.
    Title: MicroRNA-200c coordinates HNF1 homeobox B and apolipoprotein O functions to modulate lipid homeostasis in alcoholic fatty liver disease.
  5. The liver function indices (serum ALT and AST) were clearly elevated, and the ultrastructure of cellular mitochondria was distinctly altered in the liver after apoO overexpression. Further, mitochondrial membrane potential decreased with hApoO treatment in L02 cells.
    Title: Apolipoprotein O expression in mouse liver enhances hepatic lipid accumulation by impairing mitochondrial function.
  6. APOO represents a link between impaired mitochondrial function and cardiomyopathy onset, and targeting APOO-dependent metabolic remodeling has potential as a strategy to adjust heart metabolism and protect the myocardium from impaired contractility.
    Title: Apolipoprotein O is mitochondrial and promotes lipotoxicity in heart.
  7. Overexpression of apolipoprotein O does not impact on plasma HDL levels or functionality in human apolipoprotein A-I transgenic mice.
    Title: Overexpression of apolipoprotein O does not impact on plasma HDL levels or functionality in human apolipoprotein A-I transgenic mice.
  8. apolipoprotein O is the first chondroitin sulfate chain containing apolipoprotein
    Title: ApoO, a novel apolipoprotein, is an original glycoprotein up-regulated by diabetes in human heart.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC130105, MGC130106

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in cristae formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cristae formation ISO
Inferred from Sequence Orthology
more info
  
involved_in cristae formation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of MICOS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MICOS complex ISO
Inferred from Sequence Orthology
more info
  
part_of MICOS complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
MICOS complex subunit Mic26
Names
MICOS complex subunit Mic23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199337.1 → NP_001186266.1  MICOS complex subunit Mic26 isoform 2

    See identical proteins and their annotated locations for NP_001186266.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a different segment for its 5' end which utilizes an upstream start codon, compared to variant 1. The resulting protein (isoform 2) is longer when it is compared to isoform 1.
    Source sequence(s)
    AK002320, DV662362
    Consensus CDS
    CCDS57769.1
    UniProtKB/Swiss-Prot
    Q9DCZ4
    Related
    ENSMUSP00000109530.3, ENSMUST00000113897.9
    Conserved Domains (1) summary
    pfam09769
    Location:55 → 191
    ApoO; Apolipoprotein O

  2. NM_001199338.1 → NP_001186267.1  MICOS complex subunit Mic26 isoform 3

    See identical proteins and their annotated locations for NP_001186267.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains a different segment for its 5' end which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 3) has a shorter N-terminus when it is compared to isoform 1. Variants 3 and 4 encode the same protein.
    Source sequence(s)
    AK002320, AK003831, DV662362
    Consensus CDS
    CCDS57770.1
    UniProtKB/TrEMBL
    Q3KNM9
    Related
    ENSMUSP00000109529.2, ENSMUST00000113896.8
    Conserved Domains (1) summary
    pfam09769
    Location:7 → 143
    ApoO; Apolipoprotein O

  3. NM_001199339.1 → NP_001186268.1  MICOS complex subunit Mic26 isoform 3

    See identical proteins and their annotated locations for NP_001186268.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains a different segment for its 5' end which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 3) has a shorter N-terminus when it is compared to isoform 1. Variants 3 and 4 encode the same protein.
    Source sequence(s)
    AK002320, BC016557
    Consensus CDS
    CCDS57770.1
    UniProtKB/TrEMBL
    Q3KNM9
    Related
    ENSMUSP00000109528.2, ENSMUST00000113895.2
    Conserved Domains (1) summary
    pfam09769
    Location:7 → 143
    ApoO; Apolipoprotein O

  4. NM_026673.4 → NP_080949.2  MICOS complex subunit Mic26 isoform 1 precursor

    See identical proteins and their annotated locations for NP_080949.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the more frequently occurring transcript. Variant 1 encodes isoform 1.
    Source sequence(s)
    BU534555, CB595096, DV662362, EL957008
    Consensus CDS
    CCDS53136.1
    UniProtKB/Swiss-Prot
    B1ASQ2, B1ASQ3, Q9D186, Q9DCZ4
    UniProtKB/TrEMBL
    Q3KNM9
    Related
    ENSMUSP00000109531.2, ENSMUST00000113898.8
    Conserved Domains (1) summary
    pfam09769
    Location:41 → 177
    ApoO; Apolipoprotein O

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    93410615..93460699
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247666.3 → XP_011245968.1  MICOS complex subunit Mic26 isoform X1

    Conserved Domains (1) summary
    pfam09769
    Location:54 → 177
    ApoO; Apolipoprotein O

  2. XM_011247668.4 → XP_011245970.1  MICOS complex subunit Mic26 isoform X2

    See identical proteins and their annotated locations for XP_011245970.1

    Conserved Domains (1) summary
    pfam09769
    Location:20 → 143
    ApoO; Apolipoprotein O

  3. XM_011247667.4 → XP_011245969.1  MICOS complex subunit Mic26 isoform X2

    See identical proteins and their annotated locations for XP_011245969.1

    Conserved Domains (1) summary
    pfam09769
    Location:20 → 143
    ApoO; Apolipoprotein O

  4. XM_011247669.3 → XP_011245971.1  MICOS complex subunit Mic26 isoform X2

    See identical proteins and their annotated locations for XP_011245971.1

    Conserved Domains (1) summary
    pfam09769
    Location:20 → 143
    ApoO; Apolipoprotein O
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DCZ4.2 GenPept UniProtKB/Swiss-Prot:Q9DCZ4

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