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Serpina1f serine (or cysteine) peptidase inhibitor, clade A, member 1F [ Mus musculus (house mouse) ]

Gene ID: 68348, updated on 2-Nov-2024

Summary

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Official Symbol
Serpina1fprovided by MGI
Official Full Name
serine (or cysteine) peptidase inhibitor, clade A, member 1Fprovided by MGI
Primary source
MGI:MGI:1915598
See related
Ensembl:ENSMUSG00000021081 AllianceGenome:MGI:1915598
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
epserin; Serpina2; 0610012A11Rik
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be located in endoplasmic reticulum. Predicted to be active in extracellular space. Orthologous to human SERPINA2 (serpin family A member 2 (gene/pseudogene)). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward genital fat pad adult (RPKM 310.1) See more
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Genomic context

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See Serpina1f in Genome Data Viewer
Location:
12 E; 12 52.98 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (103654303..103661788, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (103688044..103695529, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 6 Neighboring gene serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 16 Neighboring gene predicted gene, 46373 Neighboring gene serine (or cysteine) preptidase inhibitor, clade A, member 1B pseudogene Neighboring gene serine (or cysteine) preptidase inhibitor, clade A, member 1B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification and characterization of novel and unknown mouse epididymis-specific genes by complementary DNA microarray technology. Yamazaki K, et al. Biol Reprod, 2006 Sep. PMID 16707773
  2. Update of the human and mouse SERPIN gene superfamily. Heit C, et al. Hum Genomics, 2013 Oct 30. PMID 24172014, Free PMC Article
  3. Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation. Cidad P, et al. J Cell Physiol, 2021 Jun. PMID 33230847
  4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha-1-antitrypsin 1-6
Names
alpha-1 protease inhibitor 6
alpha-1-antiproteinase
epididymal serine protease inhibitor
epsin
serine protease inhibitor 1-6
serine protease inhibitor A1f
serpin A1f

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164742.1 → NP_001158214.1  alpha-1-antitrypsin 1-6 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the middle portion of the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AK002574, AK165409
    Consensus CDS
    CCDS49155.1
    UniProtKB/TrEMBL
    E9PUC6, Q08EA5
    Related
    ENSMUSP00000112533.2, ENSMUST00000117053.8
    Conserved Domains (1) summary
    cl00137
    Location:55 → 351
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

  2. NM_026687.2 → NP_080963.2  alpha-1-antitrypsin 1-6 isoform 1 precursor

    See identical proteins and their annotated locations for NP_080963.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC098741, AK002574, AK165409
    Consensus CDS
    CCDS26137.1
    UniProtKB/TrEMBL
    G3X9Z5, Q08EA5
    Related
    ENSMUSP00000021490.6, ENSMUST00000021490.12
    Conserved Domains (1) summary
    pfam00079
    Location:48 → 409
    Serpin; Serpin (serine protease inhibitor)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    103654303..103661788 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DCQ7.1 GenPept UniProtKB/Swiss-Prot:Q9DCQ7

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