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Fam83c family with sequence similarity 83, member C [ Rattus norvegicus (Norway rat) ]

Gene ID: 683506, updated on 17-Aug-2024

Summary

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Official Symbol
Fam83cprovided by RGD
Official Full Name
family with sequence similarity 83, member Cprovided by RGD
Primary source
RGD:1585687
See related
EnsemblRapid:ENSRNOG00000046772 AllianceGenome:RGD:1585687
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein kinase binding activity. Predicted to be involved in signal transduction. Orthologous to human FAM83C (family with sequence similarity 83 member C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 5.5), Heart (RPKM 3.9) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
3q42
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (164792258..164799882, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (144333736..144339758, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (151365623..151371568, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 24 Neighboring gene MMP24 opposite strand Neighboring gene eukaryotic translation initiation factor 6 Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 1 Neighboring gene uncharacterized LOC134486190 Neighboring gene growth differentiation factor 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Conserved oncogenic behavior of the FAM83 family regulates MAPK signaling in human cancer. Cipriano R, et al. Mol Cancer Res, 2014 Aug. PMID 24736947, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
family with sequence similarity 83, member C; protein FAM83C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001431747.1 → NP_001418676.1  family with sequence similarity 83, member C

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    164792258..164799882 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003749599.6 → XP_003749647.1  protein FAM83C

    UniProtKB/TrEMBL
    A6KI64, M0R501
    Related
    ENSRNOP00000064456.1, ENSRNOT00000073178.3
    Conserved Domains (1) summary
    cl15239
    Location:66 → 336
    PLDc_SF; Catalytic domain of phospholipase D superfamily proteins
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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