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Cep43 centrosomal protein 43 [ Rattus norvegicus (Norway rat) ]

Gene ID: 683722, updated on 18-Sep-2024

Summary

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Official Symbol
Cep43provided by RGD
Official Full Name
centrosomal protein 43provided by RGD
Primary source
RGD:1583370
See related
EnsemblRapid:ENSRNOG00000055093 AllianceGenome:RGD:1583370
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fgfr1op
Summary
Predicted to enable protein homodimerization activity; protein kinase binding activity; and protein tyrosine kinase inhibitor activity. Predicted to be involved in several processes, including negative regulation of protein kinase activity; positive regulation of cell growth; and positive regulation of cell migration. Predicted to be located in centriole; nucleus; and perinuclear region of cytoplasm. Predicted to be active in centrosome. Orthologous to human CEP43 (centrosomal protein 43). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 119.6), Spleen (RPKM 88.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cep43 in Genome Data Viewer
Location:
1q12
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (55080983..55111509, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (52533418..52564025, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (53122330..53152872, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482722 Neighboring gene mitochondrial pyruvate carrier 1 Neighboring gene C-C motif chemokine receptor 6 Neighboring gene uncharacterized LOC134484997 Neighboring gene uncharacterized LOC134484998 Neighboring gene ribonuclease T2 Neighboring gene small Cajal body-specific RNA 3 Neighboring gene ribosomal protein S6 kinase A2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. FOP is a centriolar satellite protein involved in ciliogenesis. Lee JY, et al. PLoS One, 2013. PMID 23554904, Free PMC Article
  2. Structure of the N-terminal domain of the FOP (FGFR1OP) protein and implications for its dimerization and centrosomal localization. Mikolajka A, et al. J Mol Biol, 2006 Jun 16. PMID 16690081
  3. Fibroblast growth factor receptor 1 oncogene partner as a novel prognostic biomarker and therapeutic target for lung cancer. Mano Y, et al. Cancer Sci, 2007 Dec. PMID 17888034, Free PMC Article
  4. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine kinase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule anchoring IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell growth IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in centriole IEA
Inferred from Electronic Annotation
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
centrosomal protein 43
Names
Fgfr1 oncogene partner

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001101008.1 → NP_001094478.1  centrosomal protein 43

    See identical proteins and their annotated locations for NP_001094478.1

    Status: PROVISIONAL

    Source sequence(s)
    BC098026
    UniProtKB/Swiss-Prot
    Q4V7C1
    UniProtKB/TrEMBL
    A0A8I6GIV0
    Related
    ENSRNOP00000104874.1, ENSRNOT00000163806.1
    Conserved Domains (1) summary
    pfam09398
    Location:54 → 134
    FOP_dimer; FOP N terminal dimerization domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    55080983..55111509 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039090788.2 → XP_038946716.1  centrosomal protein 43 isoform X3

    UniProtKB/TrEMBL
    A0A8I6GIV0
    Conserved Domains (1) summary
    pfam09398
    Location:54 → 134
    FOP_dimer; FOP N terminal dimerization domain

  2. XM_008758774.4 → XP_008756996.1  centrosomal protein 43 isoform X2

    UniProtKB/TrEMBL
    A0A8I6GIV0, A0A8L2R2K1
    Related
    ENSRNOP00000070312.2, ENSRNOT00000085501.3
    Conserved Domains (1) summary
    pfam09398
    Location:54 → 134
    FOP_dimer; FOP N terminal dimerization domain

  3. XM_039090781.2 → XP_038946709.1  centrosomal protein 43 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GIV0
    Conserved Domains (1) summary
    pfam09398
    Location:54 → 134
    FOP_dimer; FOP N terminal dimerization domain

  4. XM_039090793.2 → XP_038946721.1  centrosomal protein 43 isoform X4

    Conserved Domains (1) summary
    pfam09398
    Location:54 → 134
    FOP_dimer; FOP N terminal dimerization domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4V7C1.1 GenPept UniProtKB/Swiss-Prot:Q4V7C1

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