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Mogat1 monoacylglycerol O-acyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 68393, updated on 28-Oct-2024

Summary

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Official Symbol
Mogat1provided by MGI
Official Full Name
monoacylglycerol O-acyltransferase 1provided by MGI
Primary source
MGI:MGI:1915643
See related
Ensembl:ENSMUSG00000012187 AllianceGenome:MGI:1915643
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mDC2; MGAT1; Dgat2l; Dgat2l1; 0610030A14Rik; 1110064N14Rik; WI1-2612I11.1
Summary
Enables 2-acylglycerol O-acyltransferase activity and diacylglycerol O-acyltransferase activity. Acts upstream of or within diacylglycerol biosynthetic process. Located in endoplasmic reticulum and membrane. Orthologous to human MOGAT1 (monoacylglycerol O-acyltransferase 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in stomach adult (RPKM 21.9), kidney adult (RPKM 14.0) and 3 other tissues See more
Orthologs
human all
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Genomic context

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See Mogat1 in Genome Data Viewer
Location:
1 C4; 1 40.59 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (78487697..78597882)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (78511060..78606964)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene sphingosine-1-phosphate phosphatase 2 Neighboring gene STARR-positive B cell enhancer ABC_E4327 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 2 pseudogene Neighboring gene phenylalanyl-tRNA synthetase, beta subunit Neighboring gene STARR-positive B cell enhancer ABC_E9179 Neighboring gene STARR-seq mESC enhancer starr_01427 Neighboring gene STARR-positive B cell enhancer ABC_E5774 Neighboring gene STARR-positive B cell enhancer ABC_E322 Neighboring gene predicted gene, 39665 Neighboring gene RIKEN cDNA 5730419F03 gene Neighboring gene STARR-seq mESC enhancer starr_01430 Neighboring gene STARR-seq mESC enhancer starr_01431 Neighboring gene predicted gene, 57683 Neighboring gene STARR-seq mESC enhancer starr_01433 Neighboring gene STARR-positive B cell enhancer ABC_E5775 Neighboring gene UTP14B small subunit processome component Neighboring gene acyl-CoA synthetase long-chain family member 3 Neighboring gene predicted gene, 51635

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Exercise intensity impacts the improvement of metabolic dysfunction-associated steatotic liver disease via variations of monoacylglycerol O-acyltransferase 1 expression. Baek KW, et al. Clin Res Hepatol Gastroenterol, 2024 Jan. PMID 38061546
  2. Monoacylglycerol O-acyltransferase 1 lowers adipocyte differentiation capacity in vitro but does not affect adiposity in mice. Singer JM, et al. Obesity (Silver Spring), 2022 Nov. PMID 36321276, Free PMC Article
  3. Multiple antisense oligonucleotides targeted against monoacylglycerol acyltransferase 1 (Mogat1) improve glucose metabolism independently of Mogat1. Lutkewitte AJ, et al. Mol Metab, 2021 Jul. PMID 33676028, Free PMC Article
  4. Suppression of PPARγ-mediated monoacylglycerol O-acyltransferase 1 expression ameliorates alcoholic hepatic steatosis. Yu JH, et al. Sci Rep, 2016 Jul 11. PMID 27404390, Free PMC Article
  5. Mogat1 deletion does not ameliorate hepatic steatosis in lipodystrophic (Agpat2-/-) or obese (ob/ob) mice. Agarwal AK, et al. J Lipid Res, 2016 Apr. PMID 26880786, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Exercise intensity impacts the improvement of metabolic dysfunction-associated steatotic liver disease via variations of monoacylglycerol O-acyltransferase 1 expression.
    Title: Exercise intensity impacts the improvement of metabolic dysfunction-associated steatotic liver disease via variations of monoacylglycerol O-acyltransferase 1 expression.
  2. Monoacylglycerol O-acyltransferase 1 lowers adipocyte differentiation capacity in vitro but does not affect adiposity in mice.
    Title: Monoacylglycerol O-acyltransferase 1 lowers adipocyte differentiation capacity in vitro but does not affect adiposity in mice.
  3. Multiple antisense oligonucleotides targeted against monoacylglycerol acyltransferase 1 (Mogat1) improve glucose metabolism independently of Mogat1.
    Title: Multiple antisense oligonucleotides targeted against monoacylglycerol acyltransferase 1 (Mogat1) improve glucose metabolism independently of Mogat1.
  4. demonstrate that chronic ethanol ingestion activates peroxisome proliferator-activated receptor gamma (PPARgamma) and its target gene, monoacylglycerol O-acyltransferase 1 (MGAT1)
    Title: Suppression of PPARγ-mediated monoacylglycerol O-acyltransferase 1 expression ameliorates alcoholic hepatic steatosis.
  5. a minimal role, if any, of MOGAT1 in liver TAG synthesis
    Title: Mogat1 deletion does not ameliorate hepatic steatosis in lipodystrophic (Agpat2-/-) or obese (ob/ob) mice.
  6. Inactivation of hepatic MGAT activity, which is markedly increased in obese mice, improved glucose tolerance and hepatic insulin signaling independent of changes in body weight, intrahepatic DAG and TAG content, and PKC signaling.
    Title: Abrogating monoacylglycerol acyltransferase activity in liver improves glucose tolerance and hepatic insulin signaling in obese mice.
  7. MGAT1 identified, biochemical characteristics and tissue distribution reported.
    Title: Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

General gene information

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Homology

Clone Names

  • MGC118035

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2-acylglycerol O-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables diacylglycerol O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables diacylglycerol O-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in diacylglycerol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within diacylglycerol biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycerol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in triglyceride biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in triglyceride biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
2-acylglycerol O-acyltransferase 1
Names
acyl-CoA:monoacylglycerol acyltransferase 1
diacylglycerol O-acyltransferase 2-like 1
diacylglycerol acyltransferase 2-like protein 1
NP_080989.2
XP_011237009.1
XP_017177770.1
XP_017177774.1
XP_036009175.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026713.3 → NP_080989.2  2-acylglycerol O-acyltransferase 1

    See identical proteins and their annotated locations for NP_080989.2

    Status: VALIDATED

    Source sequence(s)
    AK002693, BE626067, CB601805
    Consensus CDS
    CCDS15085.1
    UniProtKB/Swiss-Prot
    E9QLA2, Q91ZV4, Q9DCL0
    Conserved Domains (1) summary
    cl17185
    Location:41 → 335
    LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    78487697..78597882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011238707.4 → XP_011237009.1  2-acylglycerol O-acyltransferase 1 isoform X2

    UniProtKB/TrEMBL
    D3YW64
    Conserved Domains (1) summary
    cl17185
    Location:3 → 297
    LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis

  2. XM_017322281.3 → XP_017177770.1  2-acylglycerol O-acyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    E9QLA2, Q91ZV4, Q9DCL0
    Related
    ENSMUSP00000109152.2, ENSMUST00000113524.8
    Conserved Domains (1) summary
    cl17185
    Location:41 → 335
    LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis

  3. XM_036153282.1 → XP_036009175.1  2-acylglycerol O-acyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    E9QLA2, Q91ZV4, Q9DCL0
    Related
    ENSMUSP00000012331.7, ENSMUST00000012331.7
    Conserved Domains (1) summary
    cl17185
    Location:41 → 335
    LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis

  4. XM_017322285.2 → XP_017177774.1  2-acylglycerol O-acyltransferase 1 isoform X3

    Conserved Domains (1) summary
    cl17185
    Location:29 → 207
    LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis

RNA

  1. XR_004934156.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91ZV4.2 GenPept UniProtKB/Swiss-Prot:Q91ZV4

Gene LinkOut

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