Isoc2a isochorismatase domain containing 2A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Isoc2aprovided by RGD
Official Full Name: isochorismatase domain containing 2Aprovided by RGD
Primary source: RGD:1592677
See related: EnsemblRapid:ENSRNOG00000050348 AllianceGenome:RGD:1592677
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be active in cytoplasm. Orthologous to human ISOC2 (isochorismatase domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 207.2), Heart (RPKM 149.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (77967751..77986002, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (68938916..68957179, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (72491667..72509433, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH132281 (e-PCR)
- UniSTS:215564

RH127661 (e-PCR)
- UniSTS:210971

RH129229 (e-PCR)
- UniSTS:212537

M81342 (e-PCR)
- UniSTS:207770

Gene Ontology Provided by RGD

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: uncharacterized protein LOC684270

Names: isochorismatase domain-containing protein 2; isochorismatase domain-containing protein 2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001409142.1 → NP_001396071.1 uncharacterized protein LOC684270 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A6KNQ0

Related

ENSRNOP00000099798.1, ENSRNOT00000148451.1
NM_001409143.1 → NP_001396072.1 uncharacterized protein LOC684270 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

77967751..77986002 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039100618.2 → XP_038956546.1 uncharacterized protein LOC684270 isoform X1

UniProtKB/TrEMBL

A0A8I6GL72, A6KNQ0

Related

ENSRNOP00000094488.1, ENSRNOT00000097188.2

Conserved Domains (1) summary

cd01012
Location:18 → 170

YcaC_related; YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them. ...