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Glyctk glycerate kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 684314, updated on 2-Nov-2024

Summary

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Official Symbol
Glyctkprovided by RGD
Official Full Name
glycerate kinaseprovided by RGD
Primary source
RGD:1591498
See related
EnsemblRapid:ENSRNOG00000046307 AllianceGenome:RGD:1591498
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables glycerate kinase activity. Predicted to be involved in fructose catabolic process and protein phosphorylation. Is active in cytosol. Human ortholog(s) of this gene implicated in D-glyceric aciduria. Orthologous to human GLYCTK (glycerate kinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 488.8), Kidney (RPKM 468.3) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Glyctk in Genome Data Viewer
Location:
8q32
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (115676071..115681403, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (106795461..106802675, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (114846210..114853374, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L29 Neighboring gene collagen, type VI, alpha 4 Neighboring gene ribosomal protein L6, pseudogene 10 Neighboring gene microRNA let-7g Neighboring gene WD repeat domain 82 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent, 1M

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of the human D-glyceric acidemia related glycerate kinase gene GLYCTK1 and its alternatively splicing variant GLYCTK2. Guo JH, et al. DNA Seq, 2006 Feb. PMID 16753811
  2. Purification of rat liver glycerate kinase and studies of its enzymatic and immunological properties. Katayama H, et al. J Biochem, 1980 Sep. PMID 6252205
  3. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables glycerate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycerate kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycerate kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycerate kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in fructose catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
glycerate kinase
NP_001102919.1
XP_006243918.1
XP_006243919.1
XP_038938080.1
XP_038938083.1
XP_063122211.1
XP_063122212.1
XP_063122213.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109449.2 → NP_001102919.1  glycerate kinase

    See identical proteins and their annotated locations for NP_001102919.1

    Status: PROVISIONAL

    Source sequence(s)
    BC105621
    UniProtKB/Swiss-Prot
    Q0VGK3
    UniProtKB/TrEMBL
    A6I2P3
    Related
    ENSRNOP00000064339.2, ENSRNOT00000074595.3
    Conserved Domains (1) summary
    COG2379
    Location:38 → 515
    GckA; Glycerate-2-kinase [Carbohydrate transport and metabolism]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    115676071..115681403 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063266142.1 → XP_063122212.1  glycerate kinase isoform X2

  2. XM_006243857.5 → XP_006243919.1  glycerate kinase isoform X1

    See identical proteins and their annotated locations for XP_006243919.1

    UniProtKB/Swiss-Prot
    Q0VGK3
    UniProtKB/TrEMBL
    A6I2P3
    Conserved Domains (1) summary
    COG2379
    Location:38 → 515
    GckA; Glycerate-2-kinase [Carbohydrate transport and metabolism]

  3. XM_063266143.1 → XP_063122213.1  glycerate kinase isoform X2

  4. XM_039082152.2 → XP_038938080.1  glycerate kinase isoform X1

    UniProtKB/Swiss-Prot
    Q0VGK3
    UniProtKB/TrEMBL
    A6I2P3
    Conserved Domains (1) summary
    COG2379
    Location:38 → 515
    GckA; Glycerate-2-kinase [Carbohydrate transport and metabolism]

  5. XM_006243856.5 → XP_006243918.1  glycerate kinase isoform X1

    See identical proteins and their annotated locations for XP_006243918.1

    UniProtKB/Swiss-Prot
    Q0VGK3
    UniProtKB/TrEMBL
    A6I2P3
    Conserved Domains (1) summary
    COG2379
    Location:38 → 515
    GckA; Glycerate-2-kinase [Carbohydrate transport and metabolism]

  6. XM_063266141.1 → XP_063122211.1  glycerate kinase isoform X2

  7. XM_039082155.2 → XP_038938083.1  glycerate kinase isoform X3

    Conserved Domains (1) summary
    COG2379
    Location:4 → 388
    GckA; Glycerate-2-kinase [Carbohydrate transport and metabolism]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0VGK3.1 GenPept UniProtKB/Swiss-Prot:Q0VGK3

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