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Tbc1d10b TBC1 domain family, member 10b [ Mus musculus (house mouse) ]

Gene ID: 68449, updated on 28-Oct-2024

Summary

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Official Symbol
Tbc1d10bprovided by MGI
Official Full Name
TBC1 domain family, member 10bprovided by MGI
Primary source
MGI:MGI:1915699
See related
Ensembl:ENSMUSG00000042492 AllianceGenome:MGI:1915699
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110003P22Rik
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in retrograde transport, endosome to Golgi. Predicted to be located in cytosol. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human TBC1D10B (TBC1 domain family member 10B). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 22.9), ovary adult (RPKM 16.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tbc1d10b in Genome Data Viewer
Location:
7 F3; 7 69.38 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126796631..126807640, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127197459..127208468, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene TAR (HIV) RNA binding protein 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_20170 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134332123-134332276 Neighboring gene STARR-positive B cell enhancer ABC_E4977 Neighboring gene CD2 cytoplasmic tail binding protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E158 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134353944-134354145 Neighboring gene myosin light chain, phosphorylatable, fast skeletal muscle Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134361531-134361732 Neighboring gene septin 1 Neighboring gene STARR-seq mESC enhancer starr_20173 Neighboring gene STARR-seq mESC enhancer starr_20176 Neighboring gene predicted gene 4532 Neighboring gene zinc finger protein 553

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Rit1-TBC1D10B signaling modulates FcγR-mediated phagosome formation in RAW264 macrophages. Egami Y, et al. Life Sci Alliance, 2024 Oct. PMID 39084876, Free PMC Article
  2. EPI64B acts as a GTPase-activating protein for Rab27B in pancreatic acinar cells. Hou Y, et al. J Biol Chem, 2013 Jul 5. PMID 23671284, Free PMC Article
  3. Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca(2+)/CaM) and CaM Kinase II (CaMKII) Binding Partner. Evans PR, et al. J Proteome Res, 2018 Apr 6. PMID 29518331, Free PMC Article
  4. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article
  5. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rit1-TBC1D10B signaling modulates FcgammaR-mediated phagosome formation in RAW264 macrophages.
    Title: Rit1-TBC1D10B signaling modulates FcγR-mediated phagosome formation in RAW264 macrophages.
  2. EPI64B can serve as a potential physiological GAP for Rab27B and thereby participate in the regulation of exocytosis in pancreatic acinar cells.
    Title: EPI64B acts as a GTPase-activating protein for Rab27B in pancreatic acinar cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde transport, endosome to Golgi IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
TBC1 domain family member 10B
Names
protein wz3-85

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144522.5 → NP_653105.3  TBC1 domain family member 10B

    See identical proteins and their annotated locations for NP_653105.3

    Status: VALIDATED

    Source sequence(s)
    AC122537, AK047320
    Consensus CDS
    CCDS40139.2
    UniProtKB/Swiss-Prot
    Q6GQW9, Q6PIZ5, Q8BHL3, Q91XR3
    Related
    ENSMUSP00000113307.2, ENSMUST00000120705.3
    Conserved Domains (2) summary
    smart00164
    Location:343 → 548
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    PRK12323
    Location:37 → 227
    PRK12323; DNA polymerase III subunit gamma/tau

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    126796631..126807640 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BHL3.2 GenPept UniProtKB/Swiss-Prot:Q8BHL3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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