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Arhgef10l Rho guanine nucleotide exchange factor 10 like [ Rattus norvegicus (Norway rat) ]

Gene ID: 684811, updated on 2-Nov-2024

Summary

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Symbol
Arhgef10lprovided by RGD
Full Name
Rho guanine nucleotide exchange factor 10 likeprovided by RGD
Primary source
RGD:1585585
See related
EnsemblRapid:ENSRNOG00000050636 AllianceGenome:RGD:1585585
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in SREBP signaling pathway and positive regulation of stress fiber assembly. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in ovarian endometrial cancer and ovarian serous carcinoma. Orthologous to human ARHGEF10L (Rho guanine nucleotide exchange factor 10 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 118.1), Muscle (RPKM 104.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Arhgef10l in Genome Data Viewer
Location:
5q36
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (158075370..158218358, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (152792247..152935255, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (159018373..159089383, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479044 Neighboring gene uncharacterized LOC120103019 Neighboring gene uncharacterized LOC120103021 Neighboring gene uncharacterized LOC134487026 Neighboring gene uncharacterized LOC120103020

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility. Earp M, et al. PLoS One, 2018. PMID 29979793, Free PMC Article
  2. GrinchGEF--a novel Rho-specific guanine nucleotide exchange factor. Winkler S, et al. Biochem Biophys Res Commun, 2005 Oct 7. PMID 16112081
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in SREBP signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 10-like protein
Names
Rho guanine nucleotide exchange factor (GEF) 10-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427747.1 → NP_001414676.1  rho guanine nucleotide exchange factor 10-like protein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    Related
    ENSRNOP00000065550.4, ENSRNOT00000074378.5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    158075370..158218358 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063288423.1 → XP_063144493.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

    UniProtKB/TrEMBL
    M0RAV6
    Related
    ENSRNOP00000066667.3, ENSRNOT00000075382.5

  2. XM_039111324.2 → XP_038967252.1  rho guanine nucleotide exchange factor 10-like protein isoform X2

    UniProtKB/TrEMBL
    M0RBM9
    Conserved Domains (3) summary
    cd00160
    Location:276 → 460
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam19056
    Location:743 → 1234
    WD40_2; WD40 repeated domain
    pfam19057
    Location:485 → 635
    PH_19; PH domain

  3. XM_039111322.2 → XP_038967250.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

    UniProtKB/TrEMBL
    M0RAV6, M0RBM9
    Conserved Domains (3) summary
    cd00160
    Location:315 → 499
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam19056
    Location:782 → 1273
    WD40_2; WD40 repeated domain
    pfam19057
    Location:524 → 674
    PH_19; PH domain

  4. XM_063288422.1 → XP_063144492.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

    UniProtKB/TrEMBL
    M0RAV6

  5. XM_063288424.1 → XP_063144494.1  rho guanine nucleotide exchange factor 10-like protein isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZLV5
    Related
    ENSRNOP00000078748.1, ENSRNOT00000108840.2

  6. XM_039111330.2 → XP_038967258.1  rho guanine nucleotide exchange factor 10-like protein isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZYN6
    Related
    ENSRNOP00000084703.1, ENSRNOT00000103602.2
    Conserved Domains (3) summary
    cd00160
    Location:98 → 282
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam19056
    Location:565 → 1056
    WD40_2; WD40 repeated domain
    pfam19057
    Location:307 → 457
    PH_19; PH domain

  7. XM_063288425.1 → XP_063144495.1  rho guanine nucleotide exchange factor 10-like protein isoform X5

Nucleotide Protein Strain
Heading Accession and Version

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