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Ppp1r35 protein phosphatase 1, regulatory subunit 35 [ Rattus norvegicus (Norway rat) ]

Gene ID: 684993, updated on 17-Aug-2024

Summary

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Symbol
Ppp1r35provided by RGD
Full Name
protein phosphatase 1, regulatory subunit 35provided by RGD
Primary source
RGD:1584367
See related
EnsemblRapid:ENSRNOG00000084887 AllianceGenome:RGD:1584367
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable phosphatase binding activity. Predicted to be involved in negative regulation of phosphatase activity. Orthologous to human PPP1R35 (protein phosphatase 1 regulatory subunit 35). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 85.1), Thymus (RPKM 72.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
12q12
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (24552709..24556040, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (18915909..18919253, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (21727485..21728678, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene paired immunoglobin like type 2 receptor beta 2 like 7 Neighboring gene paired immunoglobulin-like type 2 receptor alpha-like Neighboring gene zinc finger CW-type and PWWP domain containing 1 Neighboring gene methylphosphate capping enzyme Neighboring gene uncharacterized LOC134481171 Neighboring gene sperm acrosome developmental regulator Neighboring gene TSC22 domain family, member 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Docking motif-guided mapping of the interactome of protein phosphatase-1. Hendrickx A, et al. Chem Biol, 2009 Apr 24. PMID 19389623
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in notochord morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of centriole elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of centriole elongation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein phosphatase 1 regulatory subunit 35
Names
protein phosphatase 1 regulatory subunit 35-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109451.1 → NP_001102921.1  protein phosphatase 1 regulatory subunit 35

    See identical proteins and their annotated locations for NP_001102921.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473973
    UniProtKB/TrEMBL
    A6IZZ9
    Related
    ENSRNOP00000111290.1, ENSRNOT00000144799.1
    Conserved Domains (1) summary
    pfam15503
    Location:107 → 253
    PPP1R35_C; Protein phosphatase 1 regulatory subunit 35 C-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    24552709..24556040 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089744.1 → XP_038945672.1  protein phosphatase 1 regulatory subunit 35 isoform X3

    Conserved Domains (1) summary
    pfam15503
    Location:107 → 158
    PPP1R35_C; Protein phosphatase 1 regulatory subunit 35 C-terminus

  2. XM_039089742.2 → XP_038945670.1  protein phosphatase 1 regulatory subunit 35 isoform X1

    UniProtKB/TrEMBL
    A6IZZ9
    Conserved Domains (1) summary
    pfam15503
    Location:107 → 253
    PPP1R35_C; Protein phosphatase 1 regulatory subunit 35 C-terminus

  3. XM_039089743.1 → XP_038945671.1  protein phosphatase 1 regulatory subunit 35 isoform X2

    Conserved Domains (1) summary
    pfam15503
    Location:107 → 158
    PPP1R35_C; Protein phosphatase 1 regulatory subunit 35 C-terminus
Nucleotide Protein Strain
Heading Accession and Version

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