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She Src homology 2 domain containing E [ Rattus norvegicus (Norway rat) ]

Gene ID: 685088, updated on 2-Nov-2024

Summary

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Official Symbol
Sheprovided by RGD
Official Full Name
Src homology 2 domain containing Eprovided by RGD
Primary source
RGD:1583215
See related
EnsemblRapid:ENSRNOG00000020797 AllianceGenome:RGD:1583215
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563897
Summary
Predicted to enable phosphotyrosine residue binding activity. Orthologous to human SHE (Src homology 2 domain containing E). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 144.7), Heart (RPKM 63.3) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See She in Genome Data Viewer
Location:
2q34
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (177559636..177585485)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (175262431..175287807)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (189169691..189194934)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ubiquitin conjugating enzyme E2 Q1 Neighboring gene uncharacterized LOC103691620 Neighboring gene interleukin 6 receptor Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene ATPase phospholipid transporting 8B2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphotyrosine residue binding IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
SH2 domain-containing adapter protein E
Names
src homology 2 domain-containing transforming protein E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001433242.1 → NP_001420171.1  SH2 domain-containing adapter protein E

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    D4A529

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    177559636..177585485
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063282723.1 → XP_063138793.1  SH2 domain-containing adapter protein E isoform X4

  2. XM_063282722.1 → XP_063138792.1  SH2 domain-containing adapter protein E isoform X3

    Related
    ENSRNOP00000098855.1, ENSRNOT00000159550.1

  3. XM_063282721.1 → XP_063138791.1  SH2 domain-containing adapter protein E isoform X1

    Related
    ENSRNOP00000076781.2, ENSRNOT00000101897.2

  4. XM_001062249.8 → XP_001062249.1  SH2 domain-containing adapter protein E isoform X2

    Related
    ENSRNOP00000028225.6, ENSRNOT00000028225.8
    Conserved Domains (1) summary
    cd10391
    Location:399 → 496
    SH2_SHE; Src homology 2 domain found in SH2 domain-containing adapter protein E (SHE)
Nucleotide Protein Strain
Heading Accession and Version

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