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Zfyve21 zinc finger, FYVE domain containing 21 [ Mus musculus (house mouse) ]

Gene ID: 68520, updated on 2-Nov-2024

Summary

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Official Symbol
Zfyve21provided by MGI
Official Full Name
zinc finger, FYVE domain containing 21provided by MGI
Primary source
MGI:MGI:1915770
See related
Ensembl:ENSMUSG00000021286 AllianceGenome:MGI:1915770
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110013H04Rik
Summary
Predicted to enable metal ion binding activity. Predicted to be located in endosome and focal adhesion. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and liver and biliary system. Orthologous to human ZFYVE21 (zinc finger FYVE-type containing 21). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 52.9), ovary adult (RPKM 50.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zfyve21 in Genome Data Viewer
Location:
12 F1; 12 61.14 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (111780600..111794822)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (111814166..111828388)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene BCL2-associated athanogene 5 Neighboring gene cytochrome c oxidase assembly factor 8 Neighboring gene STARR-seq mESC enhancer starr_33333 Neighboring gene STARR-positive B cell enhancer ABC_E7188 Neighboring gene kinesin light chain 1 Neighboring gene STARR-positive B cell enhancer ABC_E209 Neighboring gene X-ray repair complementing defective repair in Chinese hamster cells 3 Neighboring gene protein phosphatase 1, regulatory subunit 13B Neighboring gene predicted gene, 53769 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:113090021-113090249 Neighboring gene NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hedgehog-induced ZFYVE21 promotes chronic vascular inflammation by activating NLRP3 inflammasomes in T cells. Jiang B, et al. Sci Signal, 2023 Mar 21. PMID 36943921, Free PMC Article
  2. ZF21 protein, a regulator of the disassembly of focal adhesions and cancer metastasis, contains a novel noncanonical pleckstrin homology domain. Nagano M, et al. J Biol Chem, 2011 Sep 9. PMID 21768110, Free PMC Article
  3. ZFYVE21 promotes endothelial nitric oxide signaling and vascular barrier function in the kidney during aging. Jiang Q, et al. Kidney Int, 2024 Sep. PMID 38797325,
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZFYVE21 promotes endothelial nitric oxide signaling and vascular barrier function in the kidney during aging.
    Title: ZFYVE21 promotes endothelial nitric oxide signaling and vascular barrier function in the kidney during aging.
  2. Hedgehog-induced ZFYVE21 promotes chronic vascular inflammation by activating NLRP3 inflammasomes in T cells.
    Title: Hedgehog-induced ZFYVE21 promotes chronic vascular inflammation by activating NLRP3 inflammasomes in T cells.
  3. the C-terminal region is important for the ability of ZF21 to induce disassembly of FAs and cell migration, and to promote an early step of experimental metastasis to the lung
    Title: ZF21 protein, a regulator of the disassembly of focal adhesions and cancer metastasis, contains a novel noncanonical pleckstrin homology domain.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger FYVE domain-containing protein 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001374721.1 → NP_001361650.1  zinc finger FYVE domain-containing protein 21 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC152065
    Consensus CDS
    CCDS88408.1
    UniProtKB/TrEMBL
    A0A1Y7VJT0, A0A1Y7VNH4
    Related
    ENSMUSP00000152422.2, ENSMUST00000221375.2
    Conserved Domains (2) summary
    cd15727
    Location:38 → 101
    FYVE_ZF21; FYVE domain found in zinc finger FYVE domain-containing protein 21 (ZF21) and similar proteins
    pfam16696
    Location:108 → 248
    ZFYVE21_C; Zinc finger FYVE domain-containing protein 21 C-terminus

  2. NM_026752.4 → NP_081028.3  zinc finger FYVE domain-containing protein 21 isoform 1

    See identical proteins and their annotated locations for NP_081028.3

    Status: VALIDATED

    Source sequence(s)
    AC152065, BC132248
    Consensus CDS
    CCDS56865.1
    UniProtKB/Swiss-Prot
    A3KML1, Q3TBQ9, Q8VCM3, Q9D1E2
    UniProtKB/TrEMBL
    A0A1Y7VJT0
    Related
    ENSMUSP00000021714.8, ENSMUST00000021714.9
    Conserved Domains (2) summary
    cd15727
    Location:38 → 101
    FYVE_ZF21; FYVE domain found in zinc finger FYVE domain-containing protein 21 (ZF21) and similar proteins
    pfam16696
    Location:108 → 229
    ZFYVE21_C; Zinc finger FYVE domain-containing protein 21 C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    111780600..111794822
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516195.4 → XP_006516258.1  zinc finger FYVE domain-containing protein 21 isoform X3

    UniProtKB/TrEMBL
    A0A1Y7VJT0
    Conserved Domains (2) summary
    cd15727
    Location:38 → 101
    FYVE_ZF21; FYVE domain found in zinc finger FYVE domain-containing protein 21 (ZF21) and similar proteins
    pfam16696
    Location:108 → 246
    ZFYVE21_C; Zinc finger FYVE domain-containing protein 21 C-terminus

  2. XM_006516194.4 → XP_006516257.1  zinc finger FYVE domain-containing protein 21 isoform X2

    UniProtKB/TrEMBL
    A0A1Y7VJT0
    Conserved Domains (2) summary
    cd15727
    Location:38 → 101
    FYVE_ZF21; FYVE domain found in zinc finger FYVE domain-containing protein 21 (ZF21) and similar proteins
    pfam16696
    Location:108 → 247
    ZFYVE21_C; Zinc finger FYVE domain-containing protein 21 C-terminus

  3. XM_006516193.4 → XP_006516256.1  zinc finger FYVE domain-containing protein 21 isoform X1

    UniProtKB/TrEMBL
    A0A1Y7VJT0
    Related
    ENSMUSP00000152558.2, ENSMUST00000223211.2
    Conserved Domains (2) summary
    cd15727
    Location:38 → 101
    FYVE_ZF21; FYVE domain found in zinc finger FYVE domain-containing protein 21 (ZF21) and similar proteins
    pfam16696
    Location:108 → 247
    ZFYVE21_C; Zinc finger FYVE domain-containing protein 21 C-terminus

  4. XM_011244168.2 → XP_011242470.1  zinc finger FYVE domain-containing protein 21 isoform X4

    UniProtKB/TrEMBL
    A0A1Y7VJT0
    Conserved Domains (2) summary
    cd15727
    Location:38 → 101
    FYVE_ZF21; FYVE domain found in zinc finger FYVE domain-containing protein 21 (ZF21) and similar proteins
    pfam16696
    Location:108 → 228
    ZFYVE21_C; Zinc finger FYVE domain-containing protein 21 C-terminus

RNA

  1. XR_004937538.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VCM3.2 GenPept UniProtKB/Swiss-Prot:Q8VCM3

Gene LinkOut

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