Eny2 ENY2, transcription and export complex 2 subunit [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Eny2provided by RGD
Official Full Name: ENY2, transcription and export complex 2 subunitprovided by RGD
Primary source: RGD:1596439
See related: EnsemblRapid:ENSRNOG00000004681 AllianceGenome:RGD:1596439
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable chromatin binding activity and nuclear receptor coactivator activity. Involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of nucleus. Orthologous to human ENY2 (ENY2 transcription and export complex 2 subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 130.5), Kidney (RPKM 126.7) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 7q31

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (77465885..77489637)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (75581215..75605903)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (83348656..83358430)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

there is a link between the nuclear protein Eny2 and insulin secretion
Title: Suppression of the nuclear factor Eny2 increases insulin secretion in poorly functioning INS-1E insulinoma cells.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

Eny2 (e-PCR), detects polymorphism
- UniSTS:471308

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in poly(A)+ mRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in poly(A)+ mRNA export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in transcription elongation by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of DUBm complex	IBA Inferred from Biological aspect of Ancestor more info
part_of DUBm complex	ISO Inferred from Sequence Orthology more info
part_of SAGA complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SAGA complex	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
part_of nuclear pore nuclear basket	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of transcription export complex 2	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: transcription and mRNA export factor ENY2

Names: enhancer of yellow 2 homolog; enhancer of yellow 2 transcription factor homolog

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130580.1 → NP_001124052.1 transcription and mRNA export factor ENY2

See identical proteins and their annotated locations for NP_001124052.1

Status: PROVISIONAL

Source sequence(s)

CH473950

UniProtKB/TrEMBL

A6HRB0, A6HRB2

Related

ENSRNOP00000078855.2, ENSRNOT00000108113.2

Conserved Domains (1) summary

pfam10163
Location:16 → 94

EnY2; Transcription factor e(y)2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

77465885..77489637

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063264258.1 → XP_063120328.1 transcription and mRNA export factor ENY2 isoform X1

UniProtKB/TrEMBL

A0A8I5ZVD6

Related

ENSRNOP00000083166.1, ENSRNOT00000120040.2
XM_063264257.1 → XP_063120327.1 transcription and mRNA export factor ENY2 isoform X1

UniProtKB/TrEMBL

A0A8I5ZVD6
XM_039079891.2 → XP_038935819.1 transcription and mRNA export factor ENY2 isoform X2

UniProtKB/TrEMBL

A0A8I5ZLL7, A6HRB2, A6HRB3

Conserved Domains (1) summary

pfam10163
Location:11 → 89

EnY2; Transcription factor e(y)2
XM_006241615.4 → XP_006241677.1 transcription and mRNA export factor ENY2 isoform X2

See identical proteins and their annotated locations for XP_006241677.1

UniProtKB/TrEMBL

A0A8I5ZLL7, A6HRB2, A6HRB3

Conserved Domains (1) summary

pfam10163
Location:11 → 89

EnY2; Transcription factor e(y)2