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Znrf3 zinc and ring finger 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 685487, updated on 28-Oct-2024

Summary

Symbol
Znrf3provided by RGD
Full Name
zinc and ring finger 3provided by RGD
Primary source
RGD:1593771
See related
EnsemblRapid:ENSRNOG00000067305 AllianceGenome:RGD:1593771
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable frizzled binding activity and ubiquitin-protein transferase activity. Predicted to be involved in several processes, including regulation of Wnt signaling pathway; stem cell proliferation; and ubiquitin-dependent protein catabolic process. Predicted to be located in plasma membrane. Orthologous to human ZNRF3 (zinc and ring finger 3). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Adrenal (RPKM 46.3), Lung (RPKM 41.9) and 9 other tissues See more
Orthologs
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Genomic context

See Znrf3 in Genome Data Viewer
Location:
14q21
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (84375668..84527465, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (80157854..80313456, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (85527099..85586294, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene kringle containing transmembrane protein 1 Neighboring gene chromosome 14 C22orf31 homolog Neighboring gene uncharacterized LOC134481868 Neighboring gene uncharacterized LOC102549967 Neighboring gene X-box binding protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables frizzled binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase ZNRF3; similar to ring finger protein 43
Names
rCG35969-like

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    84375668..84527465 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039092844.2XP_038948772.2  E3 ubiquitin-protein ligase ZNRF3

    Related
    ENSRNOP00000097114.1, ENSRNOT00000106597.2