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Mrpl58 mitochondrial ribosomal protein L58 [ Mus musculus (house mouse) ]

Gene ID: 68572, updated on 2-Nov-2024

Summary

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Official Symbol
Mrpl58provided by MGI
Official Full Name
mitochondrial ribosomal protein L58provided by MGI
Primary source
MGI:MGI:1915822
See related
Ensembl:ENSMUSG00000018858 AllianceGenome:MGI:1915822
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ict1; MRP-L58; 1110001A02Rik; 1110002E03Rik
Summary
Predicted to enable aminoacyl-tRNA hydrolase activity and translation release factor activity, codon nonspecific. Predicted to be involved in mitochondrial translational termination and rescue of stalled ribosome. Located in mitochondrion. Is expressed in several structures, including early conceptus; eye; genitourinary system; gut; and nervous system. Orthologous to human MRPL58 (mitochondrial ribosomal protein L58). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 51.0), thymus adult (RPKM 39.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mrpl58 in Genome Data Viewer
Location:
11 E2; 11 80.84 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (115294550..115303500)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (115403724..115412674)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53654 Neighboring gene cerebellar degeneration-related protein 2-like Neighboring gene predicted gene, 32013 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115268427-115268649 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115269568-115269824 Neighboring gene STARR-seq mESC enhancer starr_31157 Neighboring gene nuclear encoded tRNA arginine 5 (anticodon CCT) Neighboring gene nuclear encoded tRNA arginine 3 (anticodon CCT)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Human Cells Require Non-stop Ribosome Rescue Activity in Mitochondria. Feaga HA, et al. PLoS Genet, 2016 Mar. PMID 27029019, Free PMC Article
  2. Solution structure of the catalytic domain of the mitochondrial protein ICT1 that is essential for cell vitality. Handa Y, et al. J Mol Biol, 2010 Nov 26. PMID 20869366
  3. Expression analysis of mammalian mitochondrial ribosomal protein genes. Cheong A, et al. Gene Expr Patterns, 2020 Dec. PMID 32987154, Free PMC Article
  4. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article
  5. Structure and Function of the Mitochondrial Ribosome. Greber BJ, et al. Annu Rev Biochem, 2016 Jun 2. PMID 27023846

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aminoacyl-tRNA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aminoacyl-tRNA hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables aminoacyl-tRNA hydrolase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables translation release factor activity, codon nonspecific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation release factor activity, codon nonspecific ISO
Inferred from Sequence Orthology
more info
  
enables translation release factor activity, codon nonspecific ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitochondrial translational termination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial translational termination ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial translational termination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in rescue of stalled ribosome ISO
Inferred from Sequence Orthology
more info
  
involved_in rescue of stalled ribosome ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial large ribosomal subunit ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of mitochondrial large ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
large ribosomal subunit protein mL62
Names
39S ribosomal protein L58, mitochondrial
immature colon carcinoma transcript 1 protein homolog
peptidyl-tRNA hydrolase ICT1, mitochondrial
NP_001334574.1
NP_001348391.1
NP_001348392.1
NP_081005.1
XP_030102123.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347645.1 → NP_001334574.1  large ribosomal subunit protein mL62 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AW495606, BB857370, BC079614, CX566707
    Consensus CDS
    CCDS83928.1
    UniProtKB/Swiss-Prot
    A2A6T2, A2A6T3, Q3TUL0, Q8R035, Q9CTK1, Q9D1R3
    Related
    ENSMUSP00000116746.2, ENSMUST00000153983.8

  2. NM_001361462.1 → NP_001348391.1  large ribosomal subunit protein mL62 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AW495606, BC079614, BY137982
    Consensus CDS
    CCDS88282.1
    UniProtKB/TrEMBL
    A2A6T4
    Related
    ENSMUSP00000102149.4, ENSMUST00000106539.10
    Conserved Domains (1) summary
    cl27687
    Location:75 → 182
    RF-1; RF-1 domain

  3. NM_001361463.1 → NP_001348392.1  large ribosomal subunit protein mL62 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL603828, AL627096
    Conserved Domains (1) summary
    cl27687
    Location:43 → 169
    RF-1; RF-1 domain

  4. NM_026729.2 → NP_081005.1  large ribosomal subunit protein mL62 isoform 1

    See identical proteins and their annotated locations for NP_081005.1

    Status: VALIDATED

    Source sequence(s)
    AK003192, AW456161, BY137982
    Consensus CDS
    CCDS25632.1
    UniProtKB/Swiss-Prot
    Q8R035
    Related
    ENSMUSP00000099325.5, ENSMUST00000103036.5
    Conserved Domains (1) summary
    cl23917
    Location:43 → 173
    RF-1; RF-1 domain

RNA

  1. NR_154991.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AW456161, BQ746449, BY137982

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    115294550..115303500
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246263.1 → XP_030102123.1  large ribosomal subunit protein mL62 isoform X1

    Conserved Domains (1) summary
    cl29584
    Location:46 → 153
    RF-1; RF-1 domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R035.1 GenPept UniProtKB/Swiss-Prot:Q8R035

Gene LinkOut

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