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Cnpy2 canopy FGF signaling regulator 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 685814, updated on 18-Sep-2024

Summary

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Official Symbol
Cnpy2provided by RGD
Official Full Name
canopy FGF signaling regulator 2provided by RGD
Primary source
RGD:1589072
See related
EnsemblRapid:ENSRNOG00000003549 AllianceGenome:RGD:1589072
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tmem4
Summary
Predicted to be active in endoplasmic reticulum. Orthologous to human CNPY2 (canopy FGF signaling regulator 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 380.5), Kidney (RPKM 366.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cnpy2 in Genome Data Viewer
Location:
7q11
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (1332293..1338081)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (748877..754352)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (2737674..2744321)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene interleukin 23 subunit alpha Neighboring gene poly(A) specific ribonuclease subunit PAN2 Neighboring gene citrate synthase Neighboring gene coenzyme Q10A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Fibroblast growth factor-21 (FGF21) regulates low-density lipoprotein receptor (LDLR) levels in cells via the E3-ubiquitin ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting saposin-like protein (Msap). Do HT, et al. J Biol Chem, 2012 Apr 13. PMID 22378787, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC156825

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of low-density lipoprotein receptor activity IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of positive regulation of low-density lipoprotein receptor activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of regulation of low-density lipoprotein particle clearance ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein canopy homolog 2
Names
canopy 2 homolog
transmembrane protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077585.1 → NP_001071053.1  protein canopy homolog 2 precursor

    Status: PROVISIONAL

    Source sequence(s)
    BC126101
    UniProtKB/TrEMBL
    A0A8I6APW9, A0A8I6GKM8, A0JN30
    Related
    ENSRNOP00000096727.1, ENSRNOT00000106896.2
    Conserved Domains (1) summary
    pfam11938
    Location:27 → 165
    DUF3456; TLR4 regulator and MIR-interacting MSAP

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    1332293..1338081
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063264262.1 → XP_063120332.1  protein canopy homolog 2 isoform X1

  2. XM_039079903.2 → XP_038935831.1  protein canopy homolog 2 isoform X2

    Conserved Domains (1) summary
    pfam11938
    Location:1 → 113
    DUF3456; TLR4 regulator and MIR-interacting MSAP
Nucleotide Protein Strain
Heading Accession and Version

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