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Lrr1 leucine rich repeat protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 685860, updated on 2-Nov-2024

Summary

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Official Symbol
Lrr1provided by RGD
Official Full Name
leucine rich repeat protein 1provided by RGD
Primary source
RGD:1589026
See related
EnsemblRapid:ENSRNOG00000004216 AllianceGenome:RGD:1589026
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ppil5
Summary
Predicted to be involved in intracellular signal transduction. Orthologous to human LRR1 (leucine rich repeat protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 26.1), Spleen (RPKM 16.0) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lrr1 in Genome Data Viewer
Location:
6q24
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (93379159..93387950)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (87643195..87651894)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (91463205..91472308)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S29 Neighboring gene RNA component of signal recognition particle 7SL1 Neighboring gene ribosomal protein L36A like 1 Neighboring gene alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
leucine-rich repeat protein 1
Names
peptidylprolyl isomerase (cyclophilin) like 5
peptidylprolyl isomerase-like 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109483.1 → NP_001102953.1  leucine-rich repeat protein 1

    See identical proteins and their annotated locations for NP_001102953.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473947
    UniProtKB/TrEMBL
    A6HBU4, D3ZE86
    Related
    ENSRNOP00000005595.4, ENSRNOT00000005595.6
    Conserved Domains (3) summary
    cd00116
    Location:162 → 314
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:164 → 186
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:163 → 220
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    93379159..93387950
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112934.2 → XP_038968862.1  leucine-rich repeat protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6ALP8
    Related
    ENSRNOP00000089761.1, ENSRNOT00000111612.2

  2. XM_008764719.4 → XP_008762941.1  leucine-rich repeat protein 1 isoform X1

    Related
    ENSRNOP00000107404.1, ENSRNOT00000139777.1
    Conserved Domains (3) summary
    cd00116
    Location:129 → 281
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:131 → 153
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:130 → 187
    LRR_8; Leucine rich repeat
Nucleotide Protein Strain
Heading Accession and Version

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