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Myl6 myosin light chain 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 685867, updated on 6-Jun-2024

Summary

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Official Symbol
Myl6provided by RGD
Official Full Name
myosin light chain 6provided by RGD
Primary source
RGD:1589019
See related
Ensembl:ENSRNOG00000054140 AllianceGenome:RGD:1589019
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
LC17; MLC-3; Myl6l
Summary
Predicted to enable microfilament motor activity. Predicted to be a structural constituent of muscle. Predicted to be involved in muscle filament sliding and skeletal muscle tissue development. Predicted to be located in brush border. Predicted to be part of unconventional myosin complex. Orthologous to human MYL6 (myosin light chain 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 1707.2), Kidney (RPKM 1472.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Myl6 in Genome Data Viewer
Location:
7q11
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (1495301..1498512, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (910764..914062, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (2906137..2909193, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene transfer RNA serine (anticodon CGA) 1 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 Neighboring gene uncharacterized LOC120093526 Neighboring gene myosin light chain 6B like 1 Neighboring gene extended synaptotagmin 1 Neighboring gene ribosomal protein S23, pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Genes up-regulated in hypertrophied ventricle. Iwai N, et al. Biochem Biophys Res Commun, 1995 Apr 17. PMID 7733921
  2. Preparation of monoclonal antibodies against human ventricular myosin light chain 1 (HVMLC1) for functional studies. Fu ZY, et al. Acta Biochim Biophys Sin (Shanghai), 2006 Sep. PMID 16953301
  3. Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function. Hailstones DL, et al. Mol Cell Biol, 1990 Mar. PMID 2304459, Free PMC Article
  4. A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins. Revenu C, et al. Mol Biol Cell, 2012 Jan. PMID 22114352, Free PMC Article
  5. Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense. Kesimer M, et al. FASEB J, 2009 Jun. PMID 19190083, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC188345

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables cytoskeletal motor activity TAS
Traceable Author Statement
more info
 PubMed 
enables microfilament motor activity ISO
Inferred from Sequence Orthology
more info
  
enables microfilament motor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables structural constituent of muscle IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of muscle ISO
Inferred from Sequence Orthology
more info
  
enables structural constituent of muscle ISS
Inferred from Sequence or Structural Similarity
more info
  
enables structural constituent of muscle TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in muscle contraction TAS
Traceable Author Statement
more info
 PubMed 
involved_in muscle filament sliding TAS
Traceable Author Statement
more info
 PubMed 
involved_in skeletal muscle tissue development TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in brush border ISO
Inferred from Sequence Orthology
more info
  
part_of myosin II complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of myosin complex TAS
Traceable Author Statement
more info
 PubMed 
part_of unconventional myosin complex ISO
Inferred from Sequence Orthology
more info
  
part_of unconventional myosin complex TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
myosin light polypeptide 6
Names
17 kDa myosin light chain
myosin light chain 3
myosin light chain A3
myosin light chain alkali 3
myosin, light chain 6, alkali, smooth muscle and non-muscle
myosin, light polypeptide 6, alkali, smooth muscle and non-muscle
myosin, light polypeptide 6, alkali, smooth muscle and non-muscle-like
non-muscle myosin alkali light chain
smooth muscle and nonmuscle myosin light chain alkali 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109484.1 → NP_001102954.1  myosin light polypeptide 6

    See identical proteins and their annotated locations for NP_001102954.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474104
    UniProtKB/Swiss-Prot
    Q64119
    UniProtKB/TrEMBL
    A6KSD7
    Conserved Domains (1) summary
    PTZ00184
    Location:5 → 149
    PTZ00184; calmodulin; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    1495301..1498512 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039079906.2 → XP_038935834.1  myosin light polypeptide 6 isoform X3

    UniProtKB/Swiss-Prot
    Q64119
    Conserved Domains (1) summary
    PTZ00184
    Location:5 → 142
    PTZ00184; calmodulin; Provisional

  2. XM_063264265.1 → XP_063120335.1  myosin light polypeptide 6 isoform X2

    UniProtKB/Swiss-Prot
    Q64119
    UniProtKB/TrEMBL
    A0A0G2K6J5, A6KSE3

  3. XM_008765039.4 → XP_008763261.1  myosin light polypeptide 6 isoform X1

    See identical proteins and their annotated locations for XP_008763261.1

    UniProtKB/Swiss-Prot
    Q64119
    UniProtKB/TrEMBL
    B2GV99
    Related
    ENSRNOP00000080100.1
    Conserved Domains (1) summary
    PTZ00184
    Location:5 → 142
    PTZ00184; calmodulin; Provisional

  4. XM_017595113.3 → XP_017450602.1  myosin light polypeptide 6 isoform X5

    UniProtKB/TrEMBL
    A6KSD9
    Conserved Domains (1) summary
    PTZ00184
    Location:1 → 114
    PTZ00184; calmodulin; Provisional

  5. XM_063264268.1 → XP_063120338.1  myosin light polypeptide 6 isoform X6

    UniProtKB/TrEMBL
    A6KSE4

  6. XM_063264266.1 → XP_063120336.1  myosin light polypeptide 6 isoform X4

  7. XM_063264267.1 → XP_063120337.1  myosin light polypeptide 6 isoform X4

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64119.3 GenPept UniProtKB/Swiss-Prot:Q64119

Gene LinkOut

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Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials