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Meis1 Meis homeobox 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 686117, updated on 10-Oct-2024

Summary

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Symbol
Meis1provided by RGD
Full Name
Meis homeobox 1provided by RGD
Primary source
RGD:1585482
See related
EnsemblRapid:ENSRNOG00000004606 AllianceGenome:RGD:1585482
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in negative regulation of cardiac muscle cell proliferation. Predicted to be located in nucleus. Predicted to be part of transcription regulator complex. Orthologous to human MEIS1 (Meis homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 362.7), Lung (RPKM 186.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Meis1 in Genome Data Viewer
Location:
14q22
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (97356949..97499646, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (93155426..93294373, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (103182178..103321809, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096677 Neighboring gene uncharacterized LOC120096678 Neighboring gene uncharacterized LOC134481793 Neighboring gene uncharacterized LOC103693204 Neighboring gene uncharacterized LOC108352806

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. MEIS1 regulated proliferation and migration of pulmonary artery smooth muscle cells in hypoxia-induced pulmonary hypertension. Yao MZ, et al. Life Sci, 2020 Aug 15. PMID 32450174
  2. Effect of changes in food consistency on NADH-ubiquinone oxidoreductase activity and levels of mRNA for ND1, 51kDa, 75kDa and myosin heavy chain isoforms in two different portions of rat masseter muscle. Ide Y, et al. Okajimas Folia Anat Jpn, 2006 Aug. PMID 16944839
  3. Hematopoietic, angiogenic and eye defects in Meis1 mutant animals. Hisa T, et al. EMBO J, 2004 Jan 28. PMID 14713950, Free PMC Article
  4. Meis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteins. Chang CP, et al. Mol Cell Biol, 1997 Oct. PMID 9315626, Free PMC Article
  5. Meis1 promotes poly (rC)-binding protein 2 expression and inhibits angiotensin II-induced cardiomyocyte hypertrophy. Zhang Y, et al. IUBMB Life, 2016 Jan. PMID 26597775

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MEIS1 regulated the proliferation and migration of pulmonary artery smooth muscle cells during hypoxia-induced pulmonary hypertension
    Title: MEIS1 regulated proliferation and migration of pulmonary artery smooth muscle cells in hypoxia-induced pulmonary hypertension.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell growth involved in cardiac muscle cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within definitive hemopoiesis ISO
Inferred from Sequence Orthology
more info
  
involved_in embryonic pattern specification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in eye development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hemopoiesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within hemopoiesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lens morphogenesis in camera-type eye ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within locomotory behavior ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within megakaryocyte development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of myeloid cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
homeobox protein Meis1
Names
Meis1, myeloid ecotropic viral integration site 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134702.1 → NP_001128174.1  homeobox protein Meis1

    See identical proteins and their annotated locations for NP_001128174.1

    Status: PROVISIONAL

    Source sequence(s)
    BC161984
    UniProtKB/TrEMBL
    B1WC31, F7EL40
    Related
    ENSRNOP00000006157.6, ENSRNOT00000006157.7
    Conserved Domains (2) summary
    pfam05920
    Location:290 → 329
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:108 → 192
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    97356949..97499646 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063273629.1 → XP_063129699.1  homeobox protein Meis1 isoform X3

    Related
    ENSRNOP00000089570.2, ENSRNOT00000104415.2

  2. XM_006251529.5 → XP_006251591.1  homeobox protein Meis1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GMM6, A6JQ06
    Conserved Domains (3) summary
    TIGR01628
    Location:326 → 449
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    pfam05920
    Location:290 → 329
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:108 → 192
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  3. XM_063273628.1 → XP_063129698.1  homeobox protein Meis1 isoform X2

  4. XM_039092455.2 → XP_038948383.1  homeobox protein Meis1 isoform X6

    Conserved Domains (2) summary
    TIGR01628
    Location:163 → 286
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    pfam05920
    Location:127 → 166
    Homeobox_KN; Homeobox KN domain

  5. XM_039092454.2 → XP_038948382.1  homeobox protein Meis1 isoform X4

    UniProtKB/TrEMBL
    B1WC31, F7EL40
    Conserved Domains (2) summary
    pfam05920
    Location:290 → 329
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:108 → 192
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  6. XM_063273630.1 → XP_063129700.1  homeobox protein Meis1 isoform X5

RNA

  1. XR_005493013.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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