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Fndc1 fibronectin type III domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 68655, updated on 2-Nov-2024

Summary

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Official Symbol
Fndc1provided by MGI
Official Full Name
fibronectin type III domain containing 1provided by MGI
Primary source
MGI:MGI:1915905
See related
Ensembl:ENSMUSG00000071984 AllianceGenome:MGI:1915905
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1866; 1110027O12Rik; 1110051A18Rik
Summary
Predicted to act upstream of or within several processes, including cellular response to hypoxia; positive regulation of cardiac muscle cell apoptotic process; and positive regulation of protein phosphorylation. Predicted to be located in cell-cell junction; mitochondrial membrane; and plasma membrane. Is expressed in alimentary system; dermis; embryo mesenchyme; eye; and salivary gland primordium. Orthologous to human FNDC1 (fibronectin type III domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in bladder adult (RPKM 10.6), limb E14.5 (RPKM 9.5) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Fndc1 in Genome Data Viewer
Location:
17 A1; 17 4.77 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (7957401..8046158, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (7738569..7827340, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33086 Neighboring gene predicted gene, 33158 Neighboring gene STARR-seq mESC enhancer starr_41759 Neighboring gene adaptor-related protein complex 3, sigma 1 subunit pseudogene Neighboring gene expressed sequence AU041480 Neighboring gene predicted gene 1604A Neighboring gene T cell activation Rho GTPase activating protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Activator of G protein signaling 8 (AGS8) is required for hypoxia-induced apoptosis of cardiomyocytes: role of G betagamma and connexin 43 (CX43). Sato M, et al. J Biol Chem, 2009 Nov 6. PMID 19723622, Free PMC Article
  2. The Rodent-Specific MicroRNA Cluster within the Sfmbt2 Gene Is Imprinted and Essential for Placental Development. Inoue K, et al. Cell Rep, 2017 May 2. PMID 28467908
  3. Genomic variants in an inbred mouse model predict mania-like behaviors. Saul MC, et al. PLoS One, 2018. PMID 29768498, Free PMC Article
  4. A large-scale in situ screen provides molecular evidence for the induction of eye anterior segment structures by the developing lens. Thut CJ, et al. Dev Biol, 2001 Mar 1. PMID 11180952
  5. Understanding the development of oral epithelial organs through single cell transcriptomic analysis. Ye Q, et al. Development, 2022 Aug 15. PMID 35831953, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Spontaneous (1)  1 citation
  • Targeted (1) 

General gene information

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Markers

Homology

Clone Names

  • KIAA1866

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within regulation of protein transport ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
fibronectin type III domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081416.3 → NP_001074885.2  fibronectin type III domain-containing protein 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC164983
    Consensus CDS
    CCDS37431.1
    UniProtKB/TrEMBL
    A0A8V5KYN9, E9Q043
    Related
    ENSMUSP00000159498.1, ENSMUST00000240702.1
    Conserved Domains (3) summary
    smart00060
    Location:103 → 186
    FN3; Fibronectin type 3 domain
    PHA03247
    Location:584 → 1157
    PHA03247; large tegument protein UL36; Provisional
    cd00063
    Location:307 → 397
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  2. NM_001403750.1 → NP_001390679.1  fibronectin type III domain-containing protein 1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC164983
    UniProtKB/TrEMBL
    A0A6I8MWX0
    Related
    ENSMUSP00000159298.2, ENSMUST00000239425.2

  3. NM_001403751.1 → NP_001390680.1  fibronectin type III domain-containing protein 1 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC164983

  4. NM_001403752.1 → NP_001390681.1  fibronectin type III domain-containing protein 1 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC164983

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    7957401..8046158 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160769.1 → XP_036016662.1  fibronectin type III domain-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    E9Q043
    Conserved Domains (3) summary
    smart00060
    Location:37 → 117
    FN3; Fibronectin type 3 domain
    PHA03247
    Location:573 → 1146
    PHA03247; large tegument protein UL36; Provisional
    cd00063
    Location:1534 → 1625
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  2. XM_006523350.5 → XP_006523413.1  fibronectin type III domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    E9Q043
    Conserved Domains (3) summary
    smart00060
    Location:37 → 117
    FN3; Fibronectin type 3 domain
    PHA03247
    Location:613 → 1186
    PHA03247; large tegument protein UL36; Provisional
    cd00063
    Location:336 → 426
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RNA

  1. XR_385179.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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