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Caprin2 caprin family member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 686779, updated on 17-Aug-2024

Summary

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Official Symbol
Caprin2provided by RGD
Official Full Name
caprin family member 2provided by RGD
Primary source
RGD:1593683
See related
EnsemblRapid:ENSRNOG00000047319 AllianceGenome:RGD:1593683
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Adir; Rng140
Summary
Predicted to enable signaling receptor binding activity. Predicted to be involved in several processes, including positive regulation of canonical Wnt signaling pathway; positive regulation of dendritic spine morphogenesis; and positive regulation of nitrogen compound metabolic process. Predicted to be located in several cellular components, including centrosome; mitochondrion; and nucleoplasm. Predicted to be part of receptor complex. Orthologous to human CAPRIN2 (caprin family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 34.3), Kidney (RPKM 33.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
4q44
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (183537935..183592162, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (181806105..181860754, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (183304993..183374195, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene hes-related family bHLH transcription factor with YRPW motif-like, pseudogene 1 Neighboring gene importin 8 Neighboring gene RNA, U2 small nuclear 45 Neighboring gene 40S ribosomal protein S23 pseudogene Neighboring gene phosphatidylinositol transfer protein, beta, pseudogene 1 Neighboring gene SIN3-HDAC complex associated factor Neighboring gene uncharacterized LOC134486897

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Unsupervised Network Analysis of the Plastic Supraoptic Nucleus Transcriptome Predicts Caprin2 Regulatory Interactions. Loh SY, et al. eNeuro, 2017 Nov-Dec. PMID 29279858, Free PMC Article
  2. RNA binding protein Caprin-2 is a pivotal regulator of the central osmotic defense response. Konopacka A, et al. Elife, 2015 Nov 12. PMID 26559902, Free PMC Article
  3. Transcriptional and Post-Transcriptional Regulation of Oxytocin and Vasopressin Gene Expression by CREB3L1 and CAPRIN2. Bárez-López S, et al. Neuroendocrinology, 2022. PMID 35051932
  4. Cloning and characterization of a gene expressed during terminal differentiation that encodes a novel inhibitor of growth. Aerbajinai W, et al. J Biol Chem, 2004 Jan 16. PMID 14593112
  5. RNA granule protein 140 (RNG140), a paralog of RNG105 localized to distinct RNA granules in neuronal dendrites in the adult vertebrate brain. Shiina N, et al. J Biol Chem, 2010 Jul 30. PMID 20516077, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Transcriptional and Post-Transcriptional Regulation of Oxytocin and Vasopressin Gene Expression by CREB3L1 and CAPRIN2.
    Title: Transcriptional and Post-Transcriptional Regulation of Oxytocin and Vasopressin Gene Expression by CREB3L1 and CAPRIN2.
  2. Using the unsupervised graphical lasso (Glasso) algorithm, study reconstructed a putative network from 500 plastic supraoptic nucleus genes in which genes are the nodes and the edges are the inferred interactions. The most active nodal gene identified within the network was Caprin2. Overexpressio or knock down Caprin2 transcripts in PC12 cells had significant opposite effects on the levels of putative target mRNAs.
    Title: Unsupervised Network Analysis of the Plastic Supraoptic Nucleus Transcriptome Predicts Caprin2 Regulatory Interactions.
  3. Caprin-2 knockdown in the hypothalamus decreases urine output and fluid intake, and increases urine osmolality, urine sodium concentration, and plasma arginine vasopressin levels.
    Title: RNA binding protein Caprin-2 is a pivotal regulator of the central osmotic defense response.
  4. RNG140 has roles in the maintenance of the dendritic structure in the adult vertebrate brain through localizing to a kind of RNA granules that are distinct from RNG105-containing granules
    Title: RNA granule protein 140 (RNG140), a paralog of RNG105 localized to distinct RNA granules in neuronal dendrites in the adult vertebrate brain.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of dendritic spine morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
caprin-2
Names
adiponectin r
cytoplasmic activation/proliferation-associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401070.1 → NP_001387999.1  caprin-2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A0S1LIA8, M0R6B1
    Related
    ENSRNOP00000109644.1, ENSRNOT00000159367.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    183537935..183592162 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063286704.1 → XP_063142774.1  caprin-2 isoform X7

    UniProtKB/TrEMBL
    A0A0S1LIA8, M0R7N7
    Related
    ENSRNOP00000065469.3, ENSRNOT00000070907.4

  2. XM_063286701.1 → XP_063142771.1  caprin-2 isoform X3

    UniProtKB/TrEMBL
    A0A0S1LIA8, A0A8I6A0V8
    Related
    ENSRNOP00000084248.1, ENSRNOT00000097069.2

  3. XM_063286703.1 → XP_063142773.1  caprin-2 isoform X5

    UniProtKB/TrEMBL
    A0A0S1LIA8

  4. XM_063286702.1 → XP_063142772.1  caprin-2 isoform X9

    UniProtKB/TrEMBL
    A0A0S1LIA8

  5. XM_063286700.1 → XP_063142770.1  caprin-2 isoform X8

    UniProtKB/TrEMBL
    A0A0S1LIA8

  6. XM_039108911.2 → XP_038964839.1  caprin-2 isoform X5

    UniProtKB/TrEMBL
    A0A0S1LIA8
    Conserved Domains (4) summary
    PRK03918
    Location:48 → 366
    PRK03918; DNA double-strand break repair ATPase Rad50
    pfam00386
    Location:839 → 964
    C1q; C1q domain
    pfam12287
    Location:528 → 775
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
    pfam18293
    Location:119 → 234
    Caprin-1_dimer; Caprin-1 dimerization domain

  7. XM_063286705.1 → XP_063142775.1  caprin-2 isoform X7

    UniProtKB/TrEMBL
    A0A0S1LIA8, M0R7N7

  8. XM_039108910.2 → XP_038964838.1  caprin-2 isoform X4

    UniProtKB/TrEMBL
    A0A0S1LIA8, M0R6B1
    Conserved Domains (4) summary
    PRK03918
    Location:48 → 366
    PRK03918; DNA double-strand break repair ATPase Rad50
    pfam00386
    Location:901 → 1026
    C1q; C1q domain
    pfam12287
    Location:528 → 837
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
    pfam18293
    Location:119 → 234
    Caprin-1_dimer; Caprin-1 dimerization domain

  9. XM_063286699.1 → XP_063142769.1  caprin-2 isoform X6

    UniProtKB/TrEMBL
    A0A0S1LIA8
    Related
    ENSRNOP00000064956.4, ENSRNOT00000073927.5

  10. XM_039108913.2 → XP_038964841.1  caprin-2 isoform X7

    UniProtKB/TrEMBL
    A0A0S1LIA8, M0R7N7
    Conserved Domains (4) summary
    PRK03918
    Location:48 → 366
    PRK03918; DNA double-strand break repair ATPase Rad50
    pfam00386
    Location:822 → 947
    C1q; C1q domain
    pfam12287
    Location:528 → 758
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
    pfam18293
    Location:119 → 234
    Caprin-1_dimer; Caprin-1 dimerization domain

  11. XM_039108908.2 → XP_038964836.1  caprin-2 isoform X3

    UniProtKB/TrEMBL
    A0A0S1LIA8, A0A8I6A0V8
    Conserved Domains (4) summary
    PRK03918
    Location:48 → 366
    PRK03918; DNA double-strand break repair ATPase Rad50
    pfam00386
    Location:867 → 992
    C1q; C1q domain
    pfam12287
    Location:528 → 803
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
    pfam18293
    Location:119 → 234
    Caprin-1_dimer; Caprin-1 dimerization domain

  12. XM_039108906.2 → XP_038964834.1  caprin-2 isoform X2

    UniProtKB/TrEMBL
    A0A0S1LIA8
    Conserved Domains (4) summary
    PRK03918
    Location:48 → 366
    PRK03918; DNA double-strand break repair ATPase Rad50
    pfam00386
    Location:899 → 1024
    C1q; C1q domain
    pfam12287
    Location:528 → 835
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
    pfam18293
    Location:119 → 234
    Caprin-1_dimer; Caprin-1 dimerization domain

  13. XM_039108905.2 → XP_038964833.1  caprin-2 isoform X1

    UniProtKB/TrEMBL
    A0A0S1LIA8
    Related
    ENSRNOP00000099753.1, ENSRNOT00000130293.1
    Conserved Domains (4) summary
    PRK03918
    Location:48 → 366
    PRK03918; DNA double-strand break repair ATPase Rad50
    pfam00386
    Location:900 → 1025
    C1q; C1q domain
    pfam12287
    Location:528 → 837
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
    pfam18293
    Location:119 → 234
    Caprin-1_dimer; Caprin-1 dimerization domain

  14. XM_063286706.1 → XP_063142776.1  caprin-2 isoform X10

    UniProtKB/TrEMBL
    A0A0S1LIA8

  15. XM_039108918.2 → XP_038964846.1  caprin-2 isoform X12

    Conserved Domains (3) summary
    pfam17380
    Location:3 → 152
    DUF5401; Family of unknown function (DUF5401)
    pfam00386
    Location:653 → 778
    C1q; C1q domain
    pfam12287
    Location:280 → 589
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term

  16. XM_039108917.2 → XP_038964845.1  caprin-2 isoform X12

    Conserved Domains (3) summary
    pfam17380
    Location:3 → 152
    DUF5401; Family of unknown function (DUF5401)
    pfam00386
    Location:653 → 778
    C1q; C1q domain
    pfam12287
    Location:280 → 589
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term

  17. XM_039108916.2 → XP_038964844.1  caprin-2 isoform X11

    UniProtKB/TrEMBL
    A0A0S1LIA8
    Conserved Domains (4) summary
    pfam17380
    Location:54 → 207
    DUF5401; Family of unknown function (DUF5401)
    pfam00386
    Location:708 → 833
    C1q; C1q domain
    pfam12287
    Location:335 → 644
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
    pfam18293
    Location:1 → 41
    Caprin-1_dimer; Caprin-1 dimerization domain

  18. XM_063286707.1 → XP_063142777.1  caprin-2 isoform X13

    UniProtKB/TrEMBL
    A6IN64
Nucleotide Protein Strain
Heading Accession and Version

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