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Ajap1 adherens junctions associated protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 687031, updated on 2-Nov-2024

Summary

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Official Symbol
Ajap1provided by RGD
Official Full Name
adherens junctions associated protein 1provided by RGD
Primary source
RGD:1590138
See related
EnsemblRapid:ENSRNOG00000050137 AllianceGenome:RGD:1590138
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
neumo48
Summary
Predicted to enable beta-catenin binding activity and protein domain specific binding activity. Predicted to be involved in negative regulation of cell-matrix adhesion; negative regulation of wound healing; and regulation of polarized epithelial cell differentiation. Predicted to be located in basolateral plasma membrane and cell surface. Predicted to be active in adherens junction; cell-cell contact zone; and cytoplasmic side of plasma membrane. Orthologous to human AJAP1 (adherens junctions associated protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 65.6), Spleen (RPKM 4.3) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Ajap1 in Genome Data Viewer
Location:
5q36
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (169190477..169302938, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (163907846..164021004, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (170615885..170679315, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S15 like 1 Neighboring gene uncharacterized LOC102550429 Neighboring gene uncharacterized LOC134479054 Neighboring gene uncharacterized LOC120102801 Neighboring gene uncharacterized LOC120103047

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Targeting of transmembrane protein shrew-1 to adherens junctions is controlled by cytoplasmic sorting motifs. Jakob V, et al. Mol Biol Cell, 2006 Aug. PMID 16707570, Free PMC Article
  2. The SHREW1 gene, frequently deleted in oligodendrogliomas, functions to inhibit cell adhesion and migration. McDonald JM, et al. Cancer Biol Ther, 2006 Mar. PMID 16410724
  3. Novel membrane protein shrew-1 targets to cadherin-mediated junctions in polarized epithelial cells. Bharti S, et al. Mol Biol Cell, 2004 Jan. PMID 14595118, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables beta-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of wound healing ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of polarized epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
  
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in cell-cell contact zone IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell-cell contact zone ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
adherens junction-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001101014.2 → NP_001094484.1  adherens junction-associated protein 1 precursor

    See identical proteins and their annotated locations for NP_001094484.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    Q4W8E7
    UniProtKB/TrEMBL
    M0R546
    Related
    ENSRNOP00000093386.1, ENSRNOT00000100046.2
    Conserved Domains (1) summary
    pfam15298
    Location:180 → 388
    AJAP1_PANP_C; AJAP1/PANP C-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    169190477..169302938 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039110790.2 → XP_038966718.1  adherens junction-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q4W8E7
    UniProtKB/TrEMBL
    M0R546
    Conserved Domains (1) summary
    pfam15298
    Location:180 → 388
    AJAP1_PANP_C; AJAP1/PANP C-terminus
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4W8E7.1 GenPept UniProtKB/Swiss-Prot:Q4W8E7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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