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Arhgef16 Rho guanine nucleotide exchange factor 16 [ Rattus norvegicus (Norway rat) ]

Gene ID: 687105, updated on 18-Sep-2024

Summary

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Official Symbol
Arhgef16provided by RGD
Official Full Name
Rho guanine nucleotide exchange factor 16provided by RGD
Primary source
RGD:1588981
See related
EnsemblRapid:ENSRNOG00000046803 AllianceGenome:RGD:1588981
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable PDZ domain binding activity; enzyme binding activity; and guanyl-nucleotide exchange factor activity. Predicted to be involved in activation of GTPase activity; cell chemotaxis; and positive regulation of protein localization to plasma membrane. Orthologous to human ARHGEF16 (Rho guanine nucleotide exchange factor 16). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 46.1), Lung (RPKM 20.6) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Arhgef16 in Genome Data Viewer
Location:
5q36
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (170126573..170148624, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (164843656..164866212, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (171626450..171649124, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene tumor protein p63 regulated 1-like Neighboring gene multiple EGF-like-domains 6 Neighboring gene PR/SET domain 16 Neighboring gene uncharacterized LOC102555433 Neighboring gene uncharacterized LOC120103049

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The HPV16 E6 binding protein Tip-1 interacts with ARHGEF16, which activates Cdc42. Oliver AW, et al. Br J Cancer, 2011 Jan 18. PMID 21139582, Free PMC Article
  2. Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism. Hiramoto-Yamaki N, et al. J Cell Biol, 2010 Aug 9. PMID 20679435, Free PMC Article
  3. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC187446

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in activation of GTPase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in activation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in cell chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 16
Names
Rho guanine nucleotide exchange factor (GEF) 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127591.1 → NP_001121063.1  rho guanine nucleotide exchange factor 16

    See identical proteins and their annotated locations for NP_001121063.1

    Status: PROVISIONAL

    Source sequence(s)
    BC166429
    UniProtKB/TrEMBL
    A0A0G2K2L6, B2GUW2
    Related
    ENSRNOP00000066478.1, ENSRNOT00000072786.4
    Conserved Domains (3) summary
    cd11938
    Location:633 → 684
    SH3_ARHGEF16_26; Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF16 and ARHGEF26
    cd01221
    Location:489 → 622
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:288 → 466
    RhoGEF; RhoGEF domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    170126573..170148624 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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