U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Brap BRCA1 associated protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 687346, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Brapprovided by RGD
Official Full Name
BRCA1 associated proteinprovided by RGD
Primary source
RGD:1586551
See related
EnsemblRapid:ENSRNOG00000046497 AllianceGenome:RGD:1586551
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity; nuclear localization sequence binding activity; and ubiquitin protein ligase activity. Predicted to be involved in Ras protein signal transduction; negative regulation of signal transduction; and protein ubiquitination. Predicted to act upstream of or within MAPK cascade. Predicted to be located in cytosol; nuclear membrane; and nucleoplasm. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human BRAP (BRCA1 associated protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 137.5), Kidney (RPKM 117.3) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Brap in Genome Data Viewer
Location:
12q16
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (40535232..40561726, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (34874533..34901030, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (40381892..40417764, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene SH2B adaptor protein 3 Neighboring gene ataxin 2 Neighboring gene F-box protein 22, pseudogene 1 Neighboring gene acyl-CoA dehydrogenase family, member 10 Neighboring gene aldehyde dehydrogenase 2 family member

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. BRAP silencing protects against neuronal inflammation, oxidative stress and apoptosis in cerebral ischemia-reperfusion injury by promoting PON1 expression. Kang T, et al. Environ Toxicol, 2023 Nov. PMID 37647369
  2. Identification of a novel cytoplasmic protein that specifically binds to nuclear localization signal motifs. Li S, et al. J Biol Chem, 1998 Mar 13. PMID 9497340
  3. Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP. Matheny SA, et al. Nature, 2004 Jan 15. PMID 14724641
  4. Interactome of the negative regulator of nuclear import BRCA1-binding protein 2. Fatima S, et al. Sci Rep, 2015 Mar 30. PMID 25820252, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. BRAP silencing protects against neuronal inflammation, oxidative stress and apoptosis in cerebral ischemia-reperfusion injury by promoting PON1 expression.
    Title: BRAP silencing protects against neuronal inflammation, oxidative stress and apoptosis in cerebral ischemia-reperfusion injury by promoting PON1 expression.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear localization sequence binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
BRCA1-associated protein
NP_001258123.1
XP_038945684.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271194.1 → NP_001258123.1  BRCA1-associated protein

    See identical proteins and their annotated locations for NP_001258123.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A0A8I5Y120, A0A8I5ZU33, A6J1D1
    Related
    ENSRNOP00000076998.1, ENSRNOT00000104886.2
    Conserved Domains (3) summary
    cd00162
    Location:262 → 303
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd12718
    Location:159 → 242
    RRM_BRAP2; RNA recognition motif in BRCA1-associated protein (BRAP2)
    pfam02148
    Location:316 → 378
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    40535232..40561726 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089756.2 → XP_038945684.1  BRCA1-associated protein isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZU33, A6J1D2
    Conserved Domains (4) summary
    COG1196
    Location:366 → 559
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd16457
    Location:231 → 274
    RING-H2_BRAP2; RING finger, H2 subclass, found in BRCA1-associated protein (BRAP2) and similar proteins
    pfam02148
    Location:286 → 348
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    cd12718
    Location:129 → 212
    RRM_BRAP2; RNA recognition motif (RRM) found in BRCA1-associated protein (BRAP2)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous