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Abhd11 abhydrolase domain containing 11 [ Mus musculus (house mouse) ]

Gene ID: 68758, updated on 2-Nov-2024

Summary

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Official Symbol
Abhd11provided by MGI
Official Full Name
abhydrolase domain containing 11provided by MGI
Primary source
MGI:MGI:1916008
See related
Ensembl:ENSMUSG00000040532 AllianceGenome:MGI:1916008
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Wbscr21; 1110054D16Rik; A630008N09Rik
Summary
Predicted to enable lipase activity. Predicted to be involved in cellular lipid metabolic process. Located in mitochondrion. Is expressed in alimentary system; ganglia; nasal septum; and submandibular gland primordium. Orthologous to human ABHD11 (abhydrolase domain containing 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in large intestine adult (RPKM 44.7), colon adult (RPKM 41.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Abhd11 in Genome Data Viewer
Location:
5 G2; 5 74.94 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (135038006..135041029)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (135009152..135012175)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene Williams Beuren syndrome chromosome region 25 (human) Neighboring gene predicted gene, 57747 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:135484761-135484944 Neighboring gene ribosomal protein S29, pseudogene Neighboring gene abhydrolase domain containing 11, opposite strand Neighboring gene syntaxin 1A (brain) Neighboring gene predicted gene, 25492 Neighboring gene BUD23, rRNA methyltransferase and ribosome maturation factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ABHD11, a new diacylglycerol lipase involved in weight gain regulation. Escoubet J, et al. PLoS One, 2020. PMID 32579589, Free PMC Article
  2. Effects of rosiglitazone and high fat diet on lipase/esterase expression in adipose tissue. Shen WJ, et al. Biochim Biophys Acta, 2007 Feb. PMID 17215164, Free PMC Article
  3. Striatal long noncoding RNA Abhd11os is neuroprotective against an N-terminal fragment of mutant huntingtin in vivo. Francelle L, et al. Neurobiol Aging, 2015 Mar. PMID 25619660
  4. Identification of additional transcripts in the Williams-Beuren syndrome critical region. Merla G, et al. Hum Genet, 2002 May. PMID 12073013
  5. Generation and comparative analysis of approximately 3.3 Mb of mouse genomic sequence orthologous to the region of human chromosome 7q11.23 implicated in Williams syndrome. DeSilva U, et al. Genome Res, 2002 Jan. PMID 11779826, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ABHD11, a new diacylglycerol lipase involved in weight gain regulation.
    Title: ABHD11, a new diacylglycerol lipase involved in weight gain regulation.
  2. loss lncRNA Abhd11os likely contribute to striatal vulnerability in HD and lncRNA may play crucial roles in neurodegenerative diseases.
    Title: Striatal long noncoding RNA Abhd11os is neuroprotective against an N-terminal fragment of mutant huntingtin in vivo.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxylic ester hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipase activity ISO
Inferred from Sequence Orthology
more info
  
enables lipase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cellular lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
part_of oxoglutarate dehydrogenase complex ISO
Inferred from Sequence Orthology
more info
  
part_of oxoglutarate dehydrogenase complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
sn-1-specific diacylglycerol lipase ABHD11
Names
Williams Beuren syndrome chromosome region 21
Williams-Beuren syndrome chromosomal region 21 protein homolog
Williams-Beuren syndrome critical region 21
abhydrolase domain-containing protein 11
alpha/beta hydrolase domain-containing protein 11
protein ABHD11
NP_001177366.1
NP_660250.1
XP_006504555.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190437.1 → NP_001177366.1  sn-1-specific diacylglycerol lipase ABHD11 isoform 2

    See identical proteins and their annotated locations for NP_001177366.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' exon and uses a downstream start codon, compared to variant 1. Isoform 2 has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC084109
    Consensus CDS
    CCDS51659.1
    UniProtKB/TrEMBL
    D3YYK0
    Related
    ENSMUSP00000106847.2, ENSMUST00000111216.8
    Conserved Domains (2) summary
    pfam00561
    Location:3 → 215
    Abhydrolase_1; alpha/beta hydrolase fold
    pfam12695
    Location:6 → 116
    Abhydrolase_5; Alpha/beta hydrolase family

  2. NM_145215.2 → NP_660250.1  sn-1-specific diacylglycerol lipase ABHD11 isoform 1

    See identical proteins and their annotated locations for NP_660250.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC084109
    Consensus CDS
    CCDS19730.1
    UniProtKB/Swiss-Prot
    Q8K4F5
    Related
    ENSMUSP00000043041.9, ENSMUST00000046999.12
    Conserved Domains (2) summary
    PRK10673
    Location:61 → 307
    PRK10673; acyl-CoA esterase; Provisional
    pfam12695
    Location:60 → 196
    Abhydrolase_5; Alpha/beta hydrolase family

RNA

  1. NR_033794.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC084109

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    135038006..135041029
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504492.4 → XP_006504555.1  sn-1-specific diacylglycerol lipase ABHD11 isoform X1

    Conserved Domains (1) summary
    PRK10673
    Location:61 → 267
    PRK10673; esterase

RNA

  1. XR_003955705.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K4F5.1 GenPept UniProtKB/Swiss-Prot:Q8K4F5

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