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Pip5kl1 phosphatidylinositol-4-phosphate 5-kinase-like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 687758, updated on 14-Nov-2024

Summary

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Official Symbol
Pip5kl1provided by RGD
Official Full Name
phosphatidylinositol-4-phosphate 5-kinase-like 1provided by RGD
Primary source
RGD:1597527
See related
EnsemblRapid:ENSRNOG00000048676 AllianceGenome:RGD:1597527
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable 1-phosphatidylinositol-4-phosphate 5-kinase activity. Predicted to be involved in several processes, including negative regulation of cell migration; negative regulation of mitochondrial membrane potential; and negative regulation of protein phosphorylation. Predicted to be located in cell projection and cytosol. Orthologous to human PIP5KL1 (phosphatidylinositol-4-phosphate 5-kinase like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 24.5), Testes (RPKM 6.7) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pip5kl1 in Genome Data Viewer
Location:
3p11
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (36258141..36266902)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (15860493..15869264)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (11592156..11597513)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486072 Neighboring gene estrogen-induced osteoclastogenesis regulator 1 Neighboring gene dolichyl-phosphate mannosyltransferase subunit 2, regulatory Neighboring gene ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 Neighboring gene ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Overexpression of PIP5KL1 suppresses cell proliferation and migration in human gastric cancer cells. Shi L, et al. Mol Biol Rep, 2010 Jun. PMID 19680787
  2. Identification and characterization of a phosphoinositide phosphate kinase homolog. Chang JD, et al. J Biol Chem, 2004 Mar 19. PMID 14701839
  3. Cell-based screening and validation of human novel genes associated with cell viability. Wang L, et al. J Biomol Screen, 2006 Jun. PMID 16751333
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of mitochondrial membrane potential ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell projection ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phosphatidylinositol 4-phosphate 5-kinase-like protein 1; phosphatidylinositol-4-phosphate 5-kinase-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001431771.1 → NP_001418700.1  phosphatidylinositol-4-phosphate 5-kinase-like 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  2. NM_001431772.1 → NP_001418701.1  phosphatidylinositol-4-phosphate 5-kinase-like 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    36258141..36266902
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039106178.2 → XP_038962106.1  phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X1

    Related
    ENSRNOP00000067014.4, ENSRNOT00000074122.4
    Conserved Domains (2) summary
    PHA03307
    Location:16 → 203
    PHA03307; transcriptional regulator ICP4; Provisional
    cd17304
    Location:262 → 604
    PIPKc_PIP5KL1; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in phosphatidylinositol 4-phosphate 5-kinase-like protein 1 (PIP5KL1) and similar proteins

  2. XM_039106179.2 → XP_038962107.1  phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X2

    Related
    ENSRNOP00000092836.2, ENSRNOT00000109105.2
    Conserved Domains (2) summary
    PHA03307
    Location:16 → 203
    PHA03307; transcriptional regulator ICP4; Provisional
    cd17304
    Location:262 → 586
    PIPKc_PIP5KL1; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in phosphatidylinositol 4-phosphate 5-kinase-like protein 1 (PIP5KL1) and similar proteins

  3. XM_039106180.2 → XP_038962108.1  phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X3

    Conserved Domains (2) summary
    PRK07764
    Location:12 → 145
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cl28923
    Location:262 → 468
    PIPKc; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family
Nucleotide Protein Strain
Heading Accession and Version

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