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Pip5kl1 phosphatidylinositol-4-phosphate 5-kinase-like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 687758, updated on 14-Nov-2024

Summary

Official Symbol
Pip5kl1provided by RGD
Official Full Name
phosphatidylinositol-4-phosphate 5-kinase-like 1provided by RGD
Primary source
RGD:1597527
See related
EnsemblRapid:ENSRNOG00000048676 AllianceGenome:RGD:1597527
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable 1-phosphatidylinositol-4-phosphate 5-kinase activity. Predicted to be involved in several processes, including negative regulation of cell migration; negative regulation of mitochondrial membrane potential; and negative regulation of protein phosphorylation. Predicted to be located in cell projection and cytosol. Orthologous to human PIP5KL1 (phosphatidylinositol-4-phosphate 5-kinase like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 24.5), Testes (RPKM 6.7) and 7 other tissues See more
Orthologs
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Genomic context

See Pip5kl1 in Genome Data Viewer
Location:
3p11
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (36258141..36266902)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (15860493..15869264)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (11592156..11597513)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486072 Neighboring gene estrogen-induced osteoclastogenesis regulator 1 Neighboring gene dolichyl-phosphate mannosyltransferase subunit 2, regulatory Neighboring gene ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 Neighboring gene ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell projection ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
phosphatidylinositol 4-phosphate 5-kinase-like protein 1; phosphatidylinositol-4-phosphate 5-kinase-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001431771.1NP_001418700.1  phosphatidylinositol-4-phosphate 5-kinase-like 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
  2. NM_001431772.1NP_001418701.1  phosphatidylinositol-4-phosphate 5-kinase-like 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    36258141..36266902
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039106178.2XP_038962106.1  phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X1

    Related
    ENSRNOP00000067014.4, ENSRNOT00000074122.4
    Conserved Domains (2) summary
    PHA03307
    Location:16203
    PHA03307; transcriptional regulator ICP4; Provisional
    cd17304
    Location:262604
    PIPKc_PIP5KL1; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in phosphatidylinositol 4-phosphate 5-kinase-like protein 1 (PIP5KL1) and similar proteins
  2. XM_039106179.2XP_038962107.1  phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X2

    Related
    ENSRNOP00000092836.2, ENSRNOT00000109105.2
    Conserved Domains (2) summary
    PHA03307
    Location:16203
    PHA03307; transcriptional regulator ICP4; Provisional
    cd17304
    Location:262586
    PIPKc_PIP5KL1; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in phosphatidylinositol 4-phosphate 5-kinase-like protein 1 (PIP5KL1) and similar proteins
  3. XM_039106180.2XP_038962108.1  phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X3

    Conserved Domains (2) summary
    PRK07764
    Location:12145
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cl28923
    Location:262468
    PIPKc; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family