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Taf11 TATA-box binding protein associated factor 11 [ Mus musculus (house mouse) ]

Gene ID: 68776, updated on 28-Oct-2024

Summary

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Official Symbol
Taf11provided by MGI
Official Full Name
TATA-box binding protein associated factor 11provided by MGI
Primary source
MGI:MGI:1916026
See related
Ensembl:ENSMUSG00000024218 AllianceGenome:MGI:1916026
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TAF2I; PRO214; TAFII28; 1110038O14Rik
Summary
Enables DNA binding activity. Predicted to be involved in positive regulation by host of viral transcription; positive regulation of transcription initiation by RNA polymerase II; and transcription by RNA polymerase II. Located in nucleus. Is expressed in brain; genitourinary system; heart; and tail. Orthologous to human TAF11 (TATA-box binding protein associated factor 11). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 14.5), testis adult (RPKM 9.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Taf11 in Genome Data Viewer
Location:
17 A3.3; 17 14.6 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (28120096..28128723, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (27901122..27909343, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:27976840-27977098 Neighboring gene U1 small nuclear ribonucleoprotein C Neighboring gene bridge-like lipid transfer protein family member 3A Neighboring gene STARR-positive B cell enhancer ABC_E7504 Neighboring gene ankyrin repeat and SAM domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_42177 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:28144121-28144327 Neighboring gene predicted gene, 35290 Neighboring gene tRNA splicing endonuclease 34 pseudogene Neighboring gene t-complex protein 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The TBN protein, which is essential for early embryonic mouse development, is an inducible TAFII implicated in adipogenesis. Guermah M, et al. Mol Cell, 2003 Oct. PMID 14580349
  2. Essential role of the TFIID subunit TAF4 in murine embryogenesis and embryonic stem cell differentiation. Langer D, et al. Nat Commun, 2016 Mar 30. PMID 27026076, Free PMC Article
  3. Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic neuronal cell death. El-Saafin F, et al. Cell Death Differ, 2022 May. PMID 35361962, Free PMC Article
  4. The TAF10-containing TFIID and SAGA transcriptional complexes are dispensable for early somitogenesis in the mouse embryo. Bardot P, et al. Development, 2017 Oct 15. PMID 28893950, Free PMC Article
  5. Dominant and redundant functions of TFIID involved in the regulation of hepatic genes. Tatarakis A, et al. Mol Cell, 2008 Aug 22. PMID 18722179

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to RNA polymerase II general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables TBP-class protein binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear thyroid hormone receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear vitamin D receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA polymerase II preinitiation complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in RNA polymerase II preinitiation complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation by host of viral transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription initiation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription initiation by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of transcription factor TFIID complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIID complex ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of transcription factor TFIID complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
transcription initiation factor TFIID subunit 11
Names
TAF(II)28
TAFII-28
TFIID subunit p30-beta
transcription initiation factor TFIID 28 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379368.1 → NP_001366297.1  transcription initiation factor TFIID subunit 11

    Status: VALIDATED

    Source sequence(s)
    AC126040
    UniProtKB/Swiss-Prot
    Q3UZH1, Q99JX1, Q9CT98
    Related
    ENSMUSP00000025057.5, ENSMUST00000025057.5
    Conserved Domains (1) summary
    pfam04719
    Location:108 → 192
    TAFII28; hTAFII28-like protein conserved region

  2. NM_026836.3 → NP_081112.1  transcription initiation factor TFIID subunit 11

    See identical proteins and their annotated locations for NP_081112.1

    Status: VALIDATED

    Source sequence(s)
    AC126040, AK050689, AK133851, BQ030498
    Consensus CDS
    CCDS28571.1
    UniProtKB/Swiss-Prot
    Q3UZH1, Q99JX1, Q9CT98
    Related
    ENSMUSP00000110498.2, ENSMUST00000114848.8
    Conserved Domains (1) summary
    pfam04719
    Location:108 → 192
    TAFII28; hTAFII28-like protein conserved region

RNA

  1. NR_166634.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC126040

  2. NR_166635.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC126040

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    28120096..28128723 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246588.4 → XP_011244890.1  transcription initiation factor TFIID subunit 11 isoform X1

    See identical proteins and their annotated locations for XP_011244890.1

    UniProtKB/Swiss-Prot
    Q3UZH1, Q99JX1, Q9CT98
    Conserved Domains (1) summary
    pfam04719
    Location:108 → 192
    TAFII28; hTAFII28-like protein conserved region

  2. XM_006524862.5 → XP_006524925.1  transcription initiation factor TFIID subunit 11 isoform X1

    See identical proteins and their annotated locations for XP_006524925.1

    UniProtKB/Swiss-Prot
    Q3UZH1, Q99JX1, Q9CT98
    Conserved Domains (1) summary
    pfam04719
    Location:108 → 192
    TAFII28; hTAFII28-like protein conserved region

  3. XM_036160772.1 → XP_036016665.1  transcription initiation factor TFIID subunit 11 isoform X2

    Conserved Domains (1) summary
    cl02176
    Location:108 → 136
    TAF11; TATA Binding Protein (TBP) Associated Factor 11 (TAF11) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

  4. XM_036160771.1 → XP_036016664.1  transcription initiation factor TFIID subunit 11 isoform X2

    Conserved Domains (1) summary
    cl02176
    Location:108 → 136
    TAF11; TATA Binding Protein (TBP) Associated Factor 11 (TAF11) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99JX1.1 GenPept UniProtKB/Swiss-Prot:Q99JX1

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