U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Suz12 SUZ12 polycomb repressive complex 2 subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 688041, updated on 10-Jul-2024

Summary

Go to the top of the page Help
Official Symbol
Suz12provided by RGD
Official Full Name
SUZ12 polycomb repressive complex 2 subunitprovided by RGD
Primary source
RGD:1593621
See related
EnsemblRapid:ENSRNOG00000058663 AllianceGenome:RGD:1593621
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including nucleic acid binding activity; promoter-specific chromatin binding activity; and transcription corepressor binding activity. Involved in several processes, including histone H3-K27 trimethylation; negative regulation of macromolecule metabolic process; and response to retinoic acid. Predicted to be located in nuclear body; nucleolus; and sex chromatin. Predicted to be part of nucleus; protein-DNA complex; and ribonucleoprotein complex. Biomarker of spina bifida. Orthologous to human SUZ12 (SUZ12 polycomb repressive complex 2 subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 186.3), Thymus (RPKM 161.0) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Suz12 in Genome Data Viewer
Location:
10q25
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (65464948..65510846)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (64967035..65012916)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (67325101..67371588)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L12-like Neighboring gene ribosomal protein L12, pseudogene 8 Neighboring gene ribosomal protein L12, pseudogene 6 Neighboring gene cytokine receptor-like factor 3 Neighboring gene ATPase family, AAA domain containing 5

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The histone H3K27 methylation mark regulates intestinal epithelial cell density-dependent proliferation and the inflammatory response. Turgeon N, et al. J Cell Biochem, 2013 May. PMID 23192652, Free PMC Article
  2. Polycomblike protein PHF1b: a transcriptional sensor for GABA receptor activity. Saha S, et al. BMC Pharmacol Toxicol, 2013 Jul 23. PMID 23879974, Free PMC Article
  3. Polycomb group proteins are essential for spinal cord development. Wang C, et al. Front Biosci (Landmark Ed), 2010 Jun 1. PMID 20515739
  4. Braveheart, a long noncoding RNA required for cardiovascular lineage commitment. Klattenhoff CA, et al. Cell, 2013 Jan 31. PMID 23352431, Free PMC Article
  5. Mutations in genes encoding polycomb repressive complex 2 subunits cause Weaver syndrome. Imagawa E, et al. Hum Mutat, 2017 Jun. PMID 28229514

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. lncRNA OL1 interacts with Suz12-PRC2 complex to orchestrate the oligodendrocyte differentiation program.
    Title: lncRNA Functional Networks in Oligodendrocytes Reveal Stage-Specific Myelination Control by an lncOL1/Suz12 Complex in the CNS.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme activator activity ISO
Inferred from Sequence Orthology
more info
  
enables histone methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables lncRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
  
enables promoter-specific chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within chromatin organization ISO
Inferred from Sequence Orthology
more info
  
involved_in facultative heterochromatin formation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of chemokine production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of tyrosine phosphorylation of STAT protein IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein modification process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within random inactivation of X chromosome ISO
Inferred from Sequence Orthology
more info
  
involved_in response to retinoic acid IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in spinal cord development IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
part_of ESC/E(Z) complex ISO
Inferred from Sequence Orthology
more info
  
part_of chromatin silencing complex ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-DNA complex ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  
part_of sex chromatin ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
polycomb protein SUZ12

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427659.1 → NP_001414588.1  polycomb protein SUZ12

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A0G2K2I0, A0A8I6AIG5
    Related
    ENSRNOP00000093177.1, ENSRNOT00000097306.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    65464948..65510846
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039087645.2 → XP_038943573.1  polycomb protein SUZ12 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JV08, A0A0G2K2I0
    Related
    ENSRNOP00000069305.2, ENSRNOT00000085914.3
    Conserved Domains (1) summary
    pfam09733
    Location:522 → 656
    VEFS-Box; VEFS-Box of polycomb protein

  2. XM_039087646.2 → XP_038943574.1  polycomb protein SUZ12 isoform X2

    UniProtKB/TrEMBL
    A6HH95
    Conserved Domains (1) summary
    pfam09733
    Location:248 → 382
    VEFS-Box; VEFS-Box of polycomb protein
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.