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Rnf157 ring finger protein 157 [ Rattus norvegicus (Norway rat) ]

Gene ID: 688272, updated on 2-Nov-2024

Summary

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Official Symbol
Rnf157provided by RGD
Official Full Name
ring finger protein 157provided by RGD
Primary source
RGD:1591154
See related
EnsemblRapid:ENSRNOG00000049862 AllianceGenome:RGD:1591154
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables ubiquitin protein ligase activity. Involved in negative regulation of apoptotic process; positive regulation of dendrite extension; and protein ubiquitination. Located in cell body and cytoplasm. Orthologous to human RNF157 (ring finger protein 157). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 128.7), Spleen (RPKM 37.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rnf157 in Genome Data Viewer
Location:
10q32.1
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (102070842..102138738, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (101571972..101639874, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (105291148..105368316, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene putative protein CRIPAK Neighboring gene exocyst complex component 7 Neighboring gene uncharacterized LOC108352160 Neighboring gene forkhead box J1 Neighboring gene UBA-like domain containing 2 Neighboring gene glutamine rich 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Regulation of neuronal survival and morphology by the E3 ubiquitin ligase RNF157. Matz A, et al. Cell Death Differ, 2015 Apr. PMID 25342469, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of dendrite extension IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 ubiquitin ligase Rnf157
Names
RING-type E3 ubiquitin transferase Rnf157
NP_001406598.1
XP_038943400.1
XP_038943402.1
XP_038943403.1
XP_038943404.1
XP_063125930.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419669.1 → NP_001406598.1  E3 ubiquitin ligase Rnf157

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    Related
    ENSRNOP00000064600.3, ENSRNOT00000075293.5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    102070842..102138738 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039087472.2 → XP_038943400.1  E3 ubiquitin ligase Rnf157 isoform X1

    UniProtKB/Swiss-Prot
    M0R5D6
    Related
    ENSRNOP00000083126.2, ENSRNOT00000103807.2
    Conserved Domains (4) summary
    cd16789
    Location:276 → 316
    mRING-HC-C3HC5_MGRN1_like---blasttree; Modified RING finger, HC subclass (C3HC5-type), found in mahogunin RING finger protein 1 (MGRN1), RING finger protein 157 (RNF157) and similar proteins
    cl29320
    Location:236 → 330
    KilA-N; KilA-N domain
    pfam03154
    Location:317 → 564
    Atrophin-1; Atrophin-1 family
    NF033913
    Location:477 → 571
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  2. XM_039087474.2 → XP_038943402.1  E3 ubiquitin ligase Rnf157 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZVF8
    Related
    ENSRNOP00000066237.4, ENSRNOT00000072230.4
    Conserved Domains (4) summary
    cd16789
    Location:276 → 316
    mRING-HC-C3HC5_MGRN1_like---blasttree; Modified RING finger, HC subclass (C3HC5-type), found in mahogunin RING finger protein 1 (MGRN1), RING finger protein 157 (RNF157) and similar proteins
    cl29320
    Location:236 → 330
    KilA-N; KilA-N domain
    pfam03154
    Location:317 → 564
    Atrophin-1; Atrophin-1 family
    NF033913
    Location:477 → 571
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  3. XM_039087475.2 → XP_038943403.1  E3 ubiquitin ligase Rnf157 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZVF8, M0R9Q8
    Conserved Domains (4) summary
    cd16789
    Location:276 → 316
    mRING-HC-C3HC5_MGRN1_like---blasttree; Modified RING finger, HC subclass (C3HC5-type), found in mahogunin RING finger protein 1 (MGRN1), RING finger protein 157 (RNF157) and similar proteins
    cl29320
    Location:236 → 330
    KilA-N; KilA-N domain
    pfam03154
    Location:317 → 564
    Atrophin-1; Atrophin-1 family
    NF033913
    Location:477 → 571
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  4. XM_039087476.2 → XP_038943404.1  E3 ubiquitin ligase Rnf157 isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZVF8
    Related
    ENSRNOP00000104746.1, ENSRNOT00000132354.1
    Conserved Domains (3) summary
    cd16789
    Location:276 → 316
    mRING-HC-C3HC5_MGRN1_like---blasttree; Modified RING finger, HC subclass (C3HC5-type), found in mahogunin RING finger protein 1 (MGRN1), RING finger protein 157 (RNF157) and similar proteins
    cl29320
    Location:236 → 330
    KilA-N; KilA-N domain
    NF033913
    Location:446 → 571
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  5. XM_063269860.1 → XP_063125930.1  E3 ubiquitin ligase Rnf157 isoform X5

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M0R5D6.2 GenPept UniProtKB/Swiss-Prot:M0R5D6

Gene LinkOut

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