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Pde6g phosphodiesterase 6G [ Rattus norvegicus (Norway rat) ]

Gene ID: 688297, updated on 13-Jul-2024

Summary

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Symbol
Pde6gprovided by RGD
Full Name
phosphodiesterase 6Gprovided by RGD
Primary source
RGD:1591130
See related
EnsemblRapid:ENSRNOG00000069361 AllianceGenome:RGD:1591130
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables spectrin binding activity. Predicted to be involved in positive regulation of G protein-coupled receptor signaling pathway and positive regulation of epidermal growth factor receptor signaling pathway. Predicted to act upstream of or within positive regulation of MAPK cascade. Predicted to be active in photoreceptor outer segment membrane. Human ortholog(s) of this gene implicated in retinitis pigmentosa 57. Orthologous to human PDE6G (phosphodiesterase 6G). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 5.2), Thymus (RPKM 3.2) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pde6g in Genome Data Viewer
Location:
10q32.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (106219849..106224496, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (105721502..105726150, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (109620499..109625214, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene FA core complex associated protein 100 Neighboring gene NPL4 homolog, ubiquitin recognition factor Neighboring gene tetraspanin 10 Neighboring gene coiled-coil domain containing 137 Neighboring gene oxidoreductase-like domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characteristics of photoreceptor PDE (PDE6): similarities and differences to PDE5. Cote RH. Int J Impot Res, 2004 Jun. PMID 15224133
  2. The inhibitory gamma subunit of the type 6 retinal cyclic guanosine monophosphate phosphodiesterase is a novel intermediate regulating p42/p44 mitogen-activated protein kinase signaling in human embryonic kidney 293 cells. Wan KF, et al. J Biol Chem, 2001 Oct 12. PMID 11502744
  3. A proline-rich domain in the gamma subunit of phosphodiesterase 6 mediates interaction with SH3-containing proteins. Morin F, et al. Mol Vis, 2003 Sep 18. PMID 14502124
  4. Photoreceptor degeneration: genetic and mechanistic dissection of a complex trait. Wright AF, et al. Nat Rev Genet, 2010 Apr. PMID 20212494
  5. Genes and mutations causing retinitis pigmentosa. Daiger SP, et al. Clin Genet, 2013 Aug. PMID 23701314, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3',5'-cyclic-GMP phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables cGMP binding IEA
Inferred from Electronic Annotation
more info
  
enables spectrin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in visual perception IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in photoreceptor outer segment membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Names
phosphodiesterase 6G, cGMP-specific, rod, gamma
NP_001385876.1
NP_001385877.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398947.1 → NP_001385876.1  retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A6HLC9, M0R4R9
    Conserved Domains (1) summary
    pfam04868
    Location:5 → 87
    PDE6_gamma; Retinal cGMP phosphodiesterase, gamma subunit

  2. NM_001398948.1 → NP_001385877.1  retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A6HLC9, M0R4R9
    Related
    ENSRNOP00000091277.1, ENSRNOT00000116189.2
    Conserved Domains (1) summary
    pfam04868
    Location:5 → 87
    PDE6_gamma; Retinal cGMP phosphodiesterase, gamma subunit

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    106219849..106224496 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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