Dipk2a divergent protein kinase domain 2A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dipk2aprovided by MGI
Official Full Name: divergent protein kinase domain 2Aprovided by MGI
Primary source: MGI:MGI:1916111
See related: Ensembl:ENSMUSG00000045414 AllianceGenome:MGI:1916111
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HASF; GoPro49; 1190002N15Rik
Summary: Acts upstream of or within negative regulation of smooth muscle cell apoptotic process. Located in COPI-coated vesicle and extracellular region. Is expressed in several structures, including cerebral cortex; embryo mesenchyme; hair follicle; jaw; and musculoskeletal system. Orthologous to human DIPK2A (divergent protein kinase domain 2A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in lung adult (RPKM 26.4), ovary adult (RPKM 25.0) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 E3.3; 9 49.03 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (94399917..94420134, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (94517864..94538081, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HASF is a novel ligand of IGF1R.
Title: HASF (C3orf58) is a novel ligand of the insulin-like growth factor 1 receptor.
HASF (GoPro49) is a stem cell paracrine factor that activates PKC epsilon mediated cytoprotection.
Title: HASF is a stem cell paracrine factor that activates PKC epsilon mediated cytoprotection.
a novel, specific marker for the dental follicle
Title: Novel Golgi protein, GoPro49, is a specific dental follicle marker.
GoPro49 is a new gene expressed specifically in mesenchymal and cartilaginous tissues during development
Title: Expression of the novel Golgi protein GoPro49 is developmentally regulated during mesenchymal differentiation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in cardiac muscle cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of smooth muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein kinase C activity	IEA Inferred from Electronic Annotation more info
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within vesicle targeting, to, from or within Golgi	IC Inferred by Curator more info	PubMed

Component	Evidence Code	Pubs
part_of COPI vesicle coat	IBA Inferred from Biological aspect of Ancestor more info
part_of COPI vesicle coat	ISO Inferred from Sequence Orthology more info
located_in COPI-coated vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: divergent protein kinase domain 2A

Names: Golgi Protein of 49 kDa; Golgi protein GoPro49; UPF0672 protein C3orf58 homolog; deleted in autism protein 1 homolog; hypoxia and AKT-induced stem cell factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.