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Cox6b1 cytochrome c oxidase subunit 6B1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 688869, updated on 2-Nov-2024

Summary

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Official Symbol
Cox6b1provided by RGD
Official Full Name
cytochrome c oxidase subunit 6B1provided by RGD
Primary source
RGD:1584097
See related
EnsemblRapid:ENSRNOG00000024309 AllianceGenome:RGD:1584097
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cox6b
Summary
Predicted to be involved in substantia nigra development. Predicted to be located in mitochondrial membrane. Predicted to be part of respiratory chain complex IV. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 7. Orthologous to human COX6B1 (cytochrome c oxidase subunit 6B1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 5203.7), Muscle (RPKM 3130.1) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cox6b1 in Genome Data Viewer
Location:
1q21
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (95002513..95011516, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (85875080..85884081, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (89075987..89084834, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 32 Neighboring gene uroplakin 1A Neighboring gene ETS variant transcription factor 2 Neighboring gene RNA binding motif protein 42

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Overexpression of COX6B1 protects against I/R‑induced neuronal injury in rat hippocampal neurons. Yang S, et al. Mol Med Rep, 2019 Jun. PMID 31059068, Free PMC Article
  2. COX6B1 relieves hypoxia/reoxygenation injury of neonatal rat cardiomyocytes by regulating mitochondrial function. Zhang W, et al. Biotechnol Lett, 2019 Jan. PMID 30311029, Free PMC Article
  3. Structure of the intact 14-subunit human cytochrome c oxidase. Zong S, et al. Cell Res, 2018 Oct. PMID 30030519, Free PMC Article
  4. Quantitative proteomic analysis of human substantia nigra in Alzheimer's disease, Huntington's disease and Multiple sclerosis. Chen S, et al. Neurochem Res, 2012 Dec. PMID 22926577
  5. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in oxidative phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in substantia nigra development ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
part_of respiratory chain complex IV IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex IV IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome c oxidase subunit 6B1
Names
COX VIb-1
cytochrome c oxidase subunit VIb
cytochrome c oxidase, subunit VIb polypeptide 1
NP_001138745.1
XP_006228857.1
XP_038947145.1
XP_063130482.1
XP_063130488.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145273.1 → NP_001138745.1  cytochrome c oxidase subunit 6B1

    See identical proteins and their annotated locations for NP_001138745.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6A8X0, A6JA04
    Conserved Domains (1) summary
    cd00926
    Location:8 → 85
    Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    95002513..95011516 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006228795.3 → XP_006228857.1  cytochrome c oxidase subunit 6B1 isoform X1

    See identical proteins and their annotated locations for XP_006228857.1

    UniProtKB/TrEMBL
    A0A8I6A8X0, A6JA04
    Conserved Domains (1) summary
    cd00926
    Location:8 → 85
    Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

  2. XM_039091217.2 → XP_038947145.1  cytochrome c oxidase subunit 6B1 isoform X2

    UniProtKB/TrEMBL
    A6JA04, D3ZSB0
    Related
    ENSRNOP00000030997.3, ENSRNOT00000032026.5
    Conserved Domains (1) summary
    cd00926
    Location:8 → 70
    Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

  3. XM_063274412.1 → XP_063130482.1  cytochrome c oxidase subunit 6B1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A8X0

  4. XM_063274418.1 → XP_063130488.1  cytochrome c oxidase subunit 6B1 isoform X2

    UniProtKB/TrEMBL
    D3ZSB0
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P80430.1 GenPept UniProtKB/Swiss-Prot:P80430

Gene LinkOut

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