Tm6sf2 transmembrane 6 superfamily member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tm6sf2provided by RGD
Official Full Name: transmembrane 6 superfamily member 2provided by RGD
Primary source: RGD:1597457
See related: EnsemblRapid:ENSRNOG00000042237 AllianceGenome:RGD:1597457
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in lipid homeostasis and regulation of lipid metabolic process. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane and endoplasmic reticulum-Golgi intermediate compartment membrane. Orthologous to human TM6SF2 (transmembrane 6 superfamily member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 142.4), Kidney (RPKM 45.2) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16p14

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (19378148..19385360, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (19344218..19351431, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (21092483..21099695, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in lipid homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of lipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of lipid metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endoplasmic reticulum-Golgi intermediate compartment membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum-Golgi intermediate compartment membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum-Golgi intermediate compartment membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: transmembrane 6 superfamily member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001127654.1 → NP_001121126.1 transmembrane 6 superfamily member 2

See identical proteins and their annotated locations for NP_001121126.1

Status: PROVISIONAL

Source sequence(s)

BC158807

UniProtKB/Swiss-Prot

B0BNG2

Related

ENSRNOP00000027800.5, ENSRNOT00000027800.9

Conserved Domains (1) summary

cd21106
Location:7 → 362

TM6SF1-like; transmembrane 6 superfamily member 1, member 2, and similar proteins