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Rad51ap1 RAD51 associated protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 689055, updated on 2-Nov-2024

Summary

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Official Symbol
Rad51ap1provided by RGD
Official Full Name
RAD51 associated protein 1provided by RGD
Primary source
RGD:1597431
See related
EnsemblRapid:ENSRNOG00000059878 AllianceGenome:RGD:1597431
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable nucleic acid binding activity. Predicted to be involved in DNA repair; cellular response to ionizing radiation; and positive regulation of DNA recombination. Predicted to act upstream of or within DNA recombination. Predicted to be located in chromatin and nucleus. Predicted to be part of protein-containing complex. Orthologous to human RAD51AP1 (RAD51 associated protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 46.9), Testes (RPKM 32.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rad51ap1 in Genome Data Viewer
Location:
4q42
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (161445610..161458661, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (159759454..159772473, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (159469803..159482869, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486843 Neighboring gene A-kinase anchoring protein 3 Neighboring gene dual specificity tyrosine phosphorylation regulated kinase 4 Neighboring gene FERRY endosomal RAB5 effector complex subunit 3 Neighboring gene ribosomal protein S2, pseudogene 33

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A novel nucleic acid-binding protein that interacts with human rad51 recombinase. Kovalenko OV, et al. Nucleic Acids Res, 1997 Dec 15. PMID 9396801, Free PMC Article
  2. RAD51AP2, a novel vertebrate- and meiotic-specific protein, shares a conserved RAD51-interacting C-terminal domain with RAD51AP1/PIR51. Kovalenko OV, et al. Nucleic Acids Res, 2006. PMID 16990250, Free PMC Article
  3. RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein. Mizuta R, et al. Proc Natl Acad Sci U S A, 1997 Jun 24. PMID 9192668, Free PMC Article
  4. NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability. Parplys AC, et al. Nucleic Acids Res, 2015 Nov 16. PMID 26323318, Free PMC Article
  5. FIGNL1-containing protein complex is required for efficient homologous recombination repair. Yuan J, et al. Proc Natl Acad Sci U S A, 2013 Jun 25. PMID 23754376, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC156698

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables D-loop DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA secondary structure binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within DNA recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in interstrand cross-link repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in interstrand cross-link repair ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of reciprocal meiotic recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RAD51-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079711.2 → NP_001073179.1  RAD51-associated protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001073179.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A8I6GE54, A1A5P3
    Related
    ENSRNOP00000073657.2, ENSRNOT00000088333.3
    Conserved Domains (1) summary
    pfam15696
    Location:303 → 330
    RAD51_interact; RAD51 interacting motif

  2. NM_001398921.1 → NP_001385850.1  RAD51-associated protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A6ILW7
    Conserved Domains (2) summary
    PTZ00459
    Location:94 → 261
    PTZ00459; mucin-associated surface protein (MASP); Provisional
    pfam15696
    Location:304 → 331
    RAD51_interact; RAD51 interacting motif

  3. NM_001398922.1 → NP_001385851.1  RAD51-associated protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    161445610..161458661 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063286719.1 → XP_063142789.1  RAD51-associated protein 1 isoform X4

    Related
    ENSRNOP00000085679.2, ENSRNOT00000119755.2

  2. XM_063286717.1 → XP_063142787.1  RAD51-associated protein 1 isoform X1

  3. XM_063286718.1 → XP_063142788.1  RAD51-associated protein 1 isoform X2

  4. XM_006237504.5 → XP_006237566.1  RAD51-associated protein 1 isoform X3

    Conserved Domains (1) summary
    PTZ00459
    Location:94 → 301
    PTZ00459; mucin-associated surface protein (MASP); Provisional

  5. XM_039108380.2 → XP_038964308.1  RAD51-associated protein 1 isoform X5

    Conserved Domains (2) summary
    PTZ00459
    Location:24 → 191
    PTZ00459; mucin-associated surface protein (MASP); Provisional
    pfam15696
    Location:234 → 261
    RAD51_interact; RAD51 interacting motif
Nucleotide Protein Strain
Heading Accession and Version

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