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Zbtb34 zinc finger and BTB domain containing 34 [ Rattus norvegicus (Norway rat) ]

Gene ID: 689174, updated on 2-Nov-2024

Summary

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Official Symbol
Zbtb34provided by RGD
Official Full Name
zinc finger and BTB domain containing 34provided by RGD
Primary source
RGD:1596130
See related
EnsemblRapid:ENSRNOG00000032700 AllianceGenome:RGD:1596130
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be active in nucleoplasm. Orthologous to human ZBTB34 (zinc finger and BTB domain containing 34). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 46.0), Spleen (RPKM 42.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zbtb34 in Genome Data Viewer
Location:
3p11
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (37101033..37123758, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (16703355..16726082, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (12452705..12468487, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101525 Neighboring gene GTPase activating Rap/RanGAP domain-like 3 Neighboring gene Ral GEF with PH domain and SH3 binding motif 1 Neighboring gene angiopoietin-like 2 Neighboring gene uncharacterized LOC102550017 Neighboring gene zinc finger and BTB domain containing 43

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399597.1 → NP_001386526.1  zinc finger and BTB domain-containing protein 34 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    Conserved Domains (5) summary
    smart00355
    Location:390 → 412
    ZnF_C2H2; zinc finger
    sd00017
    Location:392 → 412
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18220
    Location:25 → 144
    BTB_POZ_ZBTB34; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34)
    pfam00096
    Location:446 → 467
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:404 → 429
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001399598.1 → NP_001386527.1  zinc finger and BTB domain-containing protein 34 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    F1LW70
    Related
    ENSRNOP00000110918.1, ENSRNOT00000123861.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    37101033..37123758 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039106212.2 → XP_038962140.1  zinc finger and BTB domain-containing protein 34 isoform X2

    UniProtKB/TrEMBL
    A0A8I6GLG2
    Related
    ENSRNOP00000096094.1, ENSRNOT00000098831.2
    Conserved Domains (5) summary
    smart00355
    Location:388 → 410
    ZnF_C2H2; zinc finger
    sd00017
    Location:390 → 410
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18220
    Location:23 → 142
    BTB_POZ_ZBTB34; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34)
    pfam00096
    Location:444 → 465
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:402 → 427
    zf-H2C2_2; Zinc-finger double domain

  2. XM_039106211.2 → XP_038962139.1  zinc finger and BTB domain-containing protein 34 isoform X1

    Conserved Domains (5) summary
    smart00355
    Location:390 → 412
    ZnF_C2H2; zinc finger
    sd00017
    Location:392 → 412
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18220
    Location:25 → 144
    BTB_POZ_ZBTB34; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34)
    pfam00096
    Location:446 → 467
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:404 → 429
    zf-H2C2_2; Zinc-finger double domain

  3. XM_063284576.1 → XP_063140646.1  zinc finger and BTB domain-containing protein 34 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

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