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Dnajb2 DnaJ heat shock protein family (Hsp40) member B2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 689593, updated on 2-Nov-2024

Summary

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Official Symbol
Dnajb2provided by RGD
Official Full Name
DnaJ heat shock protein family (Hsp40) member B2provided by RGD
Primary source
RGD:1591035
See related
EnsemblRapid:ENSRNOG00000019506 AllianceGenome:RGD:1591035
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including Hsp70 protein binding activity; enzyme binding activity; and modification-dependent protein binding activity. Predicted to be involved in several processes, including proteasomal protein catabolic process; protein folding; and regulation of protein metabolic process. Predicted to be located in several cellular components, including endoplasmic reticulum membrane; nuclear membrane; and perinuclear region of cytoplasm. Predicted to be part of proteasome complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in autosomal recessive distal hereditary motor neuronopathy 5. Orthologous to human DNAJB2 (DnaJ heat shock protein family (Hsp40) member B2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 177.1), Brain (RPKM 160.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dnajb2 in Genome Data Viewer
Location:
9q33
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (84179702..84187942)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (76731060..76739278)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (82436453..82444669)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 16 Neighboring gene uncharacterized LOC102554903 Neighboring gene tubulin, alpha 4A Neighboring gene uncharacterized LOC120094712 Neighboring gene protein tyrosine phosphatase, receptor type, N Neighboring gene regulated endocrine-specific protein 18

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Regulation of 70-kDa heat-shock-protein ATPase activity and substrate binding by human DnaJ-like proteins, HSJ1a and HSJ1b. Cheetham ME, et al. Eur J Biochem, 1994 Nov 15. PMID 7957263
  2. The C-terminal helices of heat shock protein 70 are essential for J-domain binding and ATPase activation. Gao XC, et al. J Biol Chem, 2012 Feb 17. PMID 22219199, Free PMC Article
  3. The chaperone environment at the cytoplasmic face of the endoplasmic reticulum can modulate rhodopsin processing and inclusion formation. Chapple JP, et al. J Biol Chem, 2003 May 23. PMID 12754272
  4. Molecular chaperone mediated late-stage neuroprotection in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis. Novoselov SS, et al. PLoS One, 2013. PMID 24023695, Free PMC Article
  5. Molecular chaperone-mediated rescue of mitophagy by a Parkin RING1 domain mutant. Rose JM, et al. Hum Mol Genet, 2011 Jan 1. PMID 20889486, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase
    Title: Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables Hsp70 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Hsp70 protein binding ISO
Inferred from Sequence Orthology
more info
  
enables polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables proteasome binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-modified protein reader activity ISO
Inferred from Sequence Orthology
more info
  
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in chaperone-mediated protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chaperone-mediated protein folding ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell growth ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of inclusion body assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ATP-dependent activity IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of ATP-dependent activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein refolding ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of chaperone-mediated protein folding ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in inclusion body ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
NOT located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of proteasome complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dnaJ homolog subfamily B member 2
Names
DnaJ (Hsp40) homolog, subfamily B, member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109541.2 → NP_001103011.1  dnaJ homolog subfamily B member 2 isoform 3

    See identical proteins and their annotated locations for NP_001103011.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A6JW05, A6JW06, D4ABC2
    Related
    ENSRNOP00000026467.2, ENSRNOT00000026467.6
    Conserved Domains (2) summary
    COG0484
    Location:3 → 92
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:3 → 58
    DnaJ; DnaJ domain

  2. NM_001399115.1 → NP_001386044.1  dnaJ homolog subfamily B member 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A8I6A5U2
    Conserved Domains (1) summary
    COG0484
    Location:3 → 110
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

  3. NM_001399116.1 → NP_001386045.1  dnaJ homolog subfamily B member 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A8I6A5U2
    Conserved Domains (1) summary
    COG0484
    Location:3 → 110
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

  4. NM_001399117.1 → NP_001386046.1  dnaJ homolog subfamily B member 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    B2RYA8
    Conserved Domains (1) summary
    COG0484
    Location:3 → 110
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

  5. NM_001399118.1 → NP_001386047.1  dnaJ homolog subfamily B member 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    B2RYA8
    Conserved Domains (1) summary
    COG0484
    Location:3 → 110
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    84179702..84187942
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006245280.2 → XP_006245342.1  dnaJ homolog subfamily B member 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A3U5, A6JW06
    Conserved Domains (4) summary
    COG0484
    Location:3 → 110
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:3 → 66
    DnaJ; DnaJ domain
    pfam02809
    Location:250 → 266
    UIM; Ubiquitin interaction motif
    pfam10254
    Location:260 → 307
    Pacs-1; PACS-1 cytosolic sorting protein

  2. XM_006245281.5 → XP_006245343.1  dnaJ homolog subfamily B member 2 isoform X3

    UniProtKB/TrEMBL
    A6JW06
    Conserved Domains (2) summary
    COG0484
    Location:3 → 92
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:3 → 58
    DnaJ; DnaJ domain

  3. XM_063267756.1 → XP_063123826.1  dnaJ homolog subfamily B member 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A3U5
    Related
    ENSRNOP00000074369.2, ENSRNOT00000081958.3

  4. XM_039084218.1 → XP_038940146.1  dnaJ homolog subfamily B member 2 isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZJ88, A6JW06
    Related
    ENSRNOP00000076642.1, ENSRNOT00000098165.2
    Conserved Domains (1) summary
    COG0484
    Location:3 → 110
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

  5. XM_006245279.5 → XP_006245341.1  dnaJ homolog subfamily B member 2 isoform X1

    See identical proteins and their annotated locations for XP_006245341.1

    UniProtKB/TrEMBL
    A0A8I6A5U2, A6JW06
    Conserved Domains (1) summary
    COG0484
    Location:3 → 110
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

  6. XM_063267759.1 → XP_063123829.1  dnaJ homolog subfamily B member 2 isoform X6

    UniProtKB/TrEMBL
    B2RYA8

  7. XM_063267755.1 → XP_063123825.1  dnaJ homolog subfamily B member 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A3U5

  8. XM_063267758.1 → XP_063123828.1  dnaJ homolog subfamily B member 2 isoform X5

  9. XM_063267762.1 → XP_063123832.1  dnaJ homolog subfamily B member 2 isoform X7

    UniProtKB/TrEMBL
    A6JW05, D4ABC2

  10. XM_063267754.1 → XP_063123824.1  dnaJ homolog subfamily B member 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A5U2
    Related
    ENSRNOP00000085337.2, ENSRNOT00000095829.2

  11. XM_063267757.1 → XP_063123827.1  dnaJ homolog subfamily B member 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A3U5

  12. XM_063267761.1 → XP_063123831.1  dnaJ homolog subfamily B member 2 isoform X6

    UniProtKB/TrEMBL
    B2RYA8
Nucleotide Protein Strain
Heading Accession and Version

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