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Mcts1 malignant T cell amplified sequence 1 [ Mus musculus (house mouse) ]

Gene ID: 68995, updated on 2-Nov-2024

Summary

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Official Symbol
Mcts1provided by MGI
Official Full Name
malignant T cell amplified sequence 1provided by MGI
Primary source
MGI:MGI:1916245
See related
Ensembl:ENSMUSG00000000355 AllianceGenome:MGI:1916245
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MCT-1; 1500019M23Rik
Summary
Predicted to enable RNA cap binding activity; ribosomal small subunit binding activity; and translation factor activity, non-nucleic acid binding. Predicted to be involved in IRES-dependent viral translational initiation; cytoplasmic translational initiation; and ribosome disassembly. Predicted to be part of cytosolic small ribosomal subunit. Predicted to be active in cytoplasm. Is expressed in cerebral cortex ventricular layer; cortical plate; and embryo. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human MCTS1 (MCTS1 re-initiation and release factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E18 (RPKM 20.4), CNS E14 (RPKM 18.4) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Mcts1 in Genome Data Viewer
Location:
X A3.3; X 22.88 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (37653682..37702401)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (38600471..38613524)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 94 pseudogene Neighboring gene predicted gene 9488 Neighboring gene cullin 4B Neighboring gene STARR-seq mESC enhancer starr_47020 Neighboring gene STARR-seq mESC enhancer starr_47021 Neighboring gene STARR-seq mESC enhancer starr_47022 Neighboring gene C1GALT1-specific chaperone 1 Neighboring gene predicted gene, 52440 Neighboring gene MAK16 homolog pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cytotoxic action of acetate on tumor cells of thymic origin: Role of MCT-1, pH homeostasis and altered cell survival regulation. Pandey SK, et al. Biochimie, 2019 Feb. PMID 30391286
  2. Adaptor Protein CD2AP and L-type Lectin LMAN2 Regulate Exosome Cargo Protein Trafficking through the Golgi Complex. Kwon SH, et al. J Biol Chem, 2016 Dec 2. PMID 27765817, Free PMC Article
  3. A screen for retrotransposed imprinted genes reveals an association between X chromosome homology and maternal germ-line methylation. Wood AJ, et al. PLoS Genet, 2007 Feb 9. PMID 17291163, Free PMC Article
  4. SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation. Blewitt ME, et al. Nat Genet, 2008 May. PMID 18425126
  5. DNA methylation regulates long-range gene silencing of an X-linked homeobox gene cluster in a lineage-specific manner. Oda M, et al. Genes Dev, 2006 Dec 15. PMID 17182866, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA cap binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ribosomal small subunit binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables translation factor activity, non-nucleic acid binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in IRES-dependent viral translational initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in IRES-dependent viral translational initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in formation of translation preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in formation of translation preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
involved_in formation of translation preinitiation complex ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosome disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosome disassembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in translation reinitiation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of cytosolic small ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
malignant T-cell-amplified sequence 1
Names
multiple copies T-cell malignancies 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356359.1 → NP_001343288.1  malignant T-cell-amplified sequence 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AI845251, AL513356, AL845279
    Conserved Domains (2) summary
    cd11609
    Location:5 → 81
    MCT1_N; N-terminal domain of multiple copies T cell malignancies 1 and related proteins
    cd21155
    Location:81 → 176
    PUA_MCTS-1-like; PUA RNA-binding domain of malignant T cell-amplified sequence 1 and related proteins

  2. NM_001356360.1 → NP_001343289.1  malignant T-cell-amplified sequence 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AI845251, AK138385
    Conserved Domains (2) summary
    cd11609
    Location:5 → 81
    MCT1_N; N-terminal domain of multiple copies T cell malignancies 1 and related proteins
    cd21155
    Location:81 → 176
    PUA_MCTS-1-like; PUA RNA-binding domain of malignant T cell-amplified sequence 1 and related proteins

  3. NM_001361381.1 → NP_001348310.1  malignant T-cell-amplified sequence 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL513356, AL845279
    Conserved Domains (2) summary
    pfam17832
    Location:5 → 38
    Pre-PUA; Pre-PUA-like domain
    cd21155
    Location:29 → 124
    PUA_MCTS-1-like; PUA RNA-binding domain of malignant T cell-amplified sequence 1 and related proteins

  4. NM_001361382.1 → NP_001348311.1  malignant T-cell-amplified sequence 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AK138385, BC037103
    Related
    ENSMUST00000134573.2
    Conserved Domains (2) summary
    cd11609
    Location:5 → 81
    MCT1_N; N-terminal domain of multiple copies T cell malignancies 1 and related proteins
    cl00607
    Location:65 → 124
    PUA; PUA domain

  5. NM_026902.4 → NP_081178.1  malignant T-cell-amplified sequence 1 isoform 1

    See identical proteins and their annotated locations for NP_081178.1

    Status: VALIDATED

    Source sequence(s)
    AL513356, AL845279
    Consensus CDS
    CCDS30094.1
    UniProtKB/Swiss-Prot
    Q3UUI6, Q9DB27
    Related
    ENSMUSP00000000365.3, ENSMUST00000000365.3
    Conserved Domains (2) summary
    cd11609
    Location:4 → 80
    MCT1_N; N-terminal domain of multiple copies T cell malignancies 1 and related proteins
    cd21155
    Location:80 → 175
    PUA_MCTS-1-like; PUA RNA-binding domain of malignant T cell-amplified sequence 1 and related proteins

RNA

  1. NR_154890.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AA914196, AI845251, AL513356

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    37653682..37702401
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162088.1 → XP_036017981.1  malignant T-cell-amplified sequence 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3UUI6, Q9DB27
    Conserved Domains (2) summary
    cd11609
    Location:4 → 80
    MCT1_N; N-terminal domain of multiple copies T cell malignancies 1 and related proteins
    cd21155
    Location:80 → 175
    PUA_MCTS-1-like; PUA RNA-binding domain of malignant T cell-amplified sequence 1 and related proteins

RNA

  1. XR_004940363.1 RNA Sequence

  2. XR_004940362.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DB27.1 GenPept UniProtKB/Swiss-Prot:Q9DB27

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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