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Gpr137 G protein-coupled receptor 137 [ Rattus norvegicus (Norway rat) ]

Gene ID: 689984, updated on 2-Nov-2024

Summary

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Official Symbol
Gpr137provided by RGD
Official Full Name
G protein-coupled receptor 137provided by RGD
Primary source
RGD:1586317
See related
EnsemblRapid:ENSRNOG00000021145 AllianceGenome:RGD:1586317
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in several processes, including negative regulation of bone resorption; negative regulation of osteoclast differentiation; and positive regulation of TORC1 signaling. Predicted to be active in lysosomal membrane. Orthologous to human GPR137 (G protein-coupled receptor 137). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 93.5), Testes (RPKM 57.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gpr137 in Genome Data Viewer
Location:
1q43
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (213558846..213562422, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (204129636..204132622, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (222194266..222197252, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene catsper channel auxiliary subunit zeta Neighboring gene uncharacterized LOC134483962 Neighboring gene potassium two pore domain channel subfamily K member 4 Neighboring gene BCL2-associated agonist of cell death Neighboring gene phospholipase C beta 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1 localization and activity. Gan L, et al. Nat Cell Biol, 2019 May. PMID 31036939, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in negative regulation of bone resorption IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of osteoclast differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
integral membrane protein GPR137

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109562.2 → NP_001103032.1  integral membrane protein GPR137

    See identical proteins and their annotated locations for NP_001103032.1

    Status: PROVISIONAL

    Source sequence(s)
    BC167037
    UniProtKB/TrEMBL
    B2RZ60, F7FBZ9
    Conserved Domains (1) summary
    cd21474
    Location:16 → 325
    7tm_GPR137A; Integral membrane protein GPR137A, an orphan receptor member of the seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    213558846..213562422 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063274672.1 → XP_063130742.1  integral membrane protein GPR137 isoform X1

RNA

  1. XR_010057854.1 RNA Sequence

    Related
    ENSRNOT00000116359.2
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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