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Nbas NBAS subunit of NRZ tethering complex [ Rattus norvegicus (Norway rat) ]

Gene ID: 690073, updated on 2-Nov-2024

Summary

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Official Symbol
Nbasprovided by RGD
Official Full Name
NBAS subunit of NRZ tethering complexprovided by RGD
Primary source
RGD:1585140
See related
EnsemblRapid:ENSRNOG00000024503 AllianceGenome:RGD:1585140
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable SNARE binding activity. Predicted to be involved in negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nuclear-transcribed mRNA catabolic process; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to be located in endoplasmic reticulum. Predicted to be part of Dsl1/NZR complex. Human ortholog(s) of this gene implicated in infantile liver failure syndrome. Orthologous to human NBAS (NBAS subunit of NRZ tethering complex). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 119.4), Kidney (RPKM 92.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nbas in Genome Data Viewer
Location:
6q15
Exon count:
53
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (41777253..42081895)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (36048357..36353206)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (38474773..38777146)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479281 Neighboring gene large ribosomal subunit protein eL8-like Neighboring gene DEAD-box helicase 1 Neighboring gene ferritin light chain 1 pseudogene Neighboring gene uncharacterized LOC120103514 Neighboring gene uncharacterized LOC120103515 Neighboring gene uncharacterized LOC134479343

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Recurrent acute liver failure due to NBAS deficiency: phenotypic spectrum, disease mechanisms, and therapeutic concepts. Staufner C, et al. J Inherit Metab Dis, 2016 Jan. PMID 26541327
  2. Identification of the neuroblastoma-amplified gene product as a component of the syntaxin 18 complex implicated in Golgi-to-endoplasmic reticulum retrograde transport. Aoki T, et al. Mol Biol Cell, 2009 Jun. PMID 19369418, Free PMC Article
  3. Structural analysis of the RZZ complex reveals common ancestry with multisubunit vesicle tethering machinery. Civril F, et al. Structure, 2010 May 12. PMID 20462495
  4. DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans. Longman D, et al. Nucleic Acids Res, 2013 Sep. PMID 23828042, Free PMC Article
  5. Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. Bhatnagar S, et al. J Biol Chem, 2014 Sep 5. PMID 25002582, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNARE binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear-transcribed mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Dsl1/NZR complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Dsl1/NZR complex ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
NBAS subunit of NRZ tethering complex
Names
neuroblastoma amplified sequence
neuroblastoma-amplified protein-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427446.1 → NP_001414375.1  NBAS subunit of NRZ tethering complex

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    Related
    ENSRNOP00000109856.1, ENSRNOT00000142568.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    41777253..42081895
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063262517.1 → XP_063118587.1  NBAS subunit of NRZ tethering complex isoform X9

  2. XM_063262512.1 → XP_063118582.1  NBAS subunit of NRZ tethering complex isoform X1

  3. XM_063262514.1 → XP_063118584.1  NBAS subunit of NRZ tethering complex isoform X3

  4. XM_063262515.1 → XP_063118585.1  NBAS subunit of NRZ tethering complex isoform X4

  5. XM_006239902.5 → XP_006239964.1  NBAS subunit of NRZ tethering complex isoform X5

    UniProtKB/TrEMBL
    A0A8I6AM92
    Conserved Domains (2) summary
    pfam08314
    Location:725 → 1369
    Sec39; Secretory pathway protein Sec39
    pfam15492
    Location:89 → 370
    Nbas_N; Neuroblastoma-amplified sequence, N terminal

  6. XM_039113134.2 → XP_038969062.1  NBAS subunit of NRZ tethering complex isoform X7

    UniProtKB/TrEMBL
    A0A8I6AM92
    Conserved Domains (2) summary
    pfam08314
    Location:725 → 1364
    Sec39; Secretory pathway protein Sec39
    pfam15492
    Location:89 → 370
    Nbas_N; Neuroblastoma-amplified sequence, N terminal

  7. XM_063262513.1 → XP_063118583.1  NBAS subunit of NRZ tethering complex isoform X2

  8. XM_006239903.5 → XP_006239965.1  NBAS subunit of NRZ tethering complex isoform X6

    UniProtKB/TrEMBL
    A0A8I6AM92
    Conserved Domains (2) summary
    pfam08314
    Location:725 → 1369
    Sec39; Secretory pathway protein Sec39
    pfam15492
    Location:89 → 370
    Nbas_N; Neuroblastoma-amplified sequence, N terminal

  9. XM_006239904.5 → XP_006239966.1  NBAS subunit of NRZ tethering complex isoform X8

    UniProtKB/TrEMBL
    A0A8I6AM92, F1M0U5
    Related
    ENSRNOP00000009779.8, ENSRNOT00000009779.9
    Conserved Domains (2) summary
    pfam08314
    Location:725 → 1369
    Sec39; Secretory pathway protein Sec39
    pfam15492
    Location:89 → 370
    Nbas_N; Neuroblastoma-amplified sequence, N terminal

  10. XM_063262518.1 → XP_063118588.1  NBAS subunit of NRZ tethering complex isoform X10

Nucleotide Protein Strain
Heading Accession and Version

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