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Adat1 adenosine deaminase, tRNA-specific 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 690810, updated on 2-Nov-2024

Summary

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Official Symbol
Adat1provided by RGD
Official Full Name
adenosine deaminase, tRNA-specific 1provided by RGD
Primary source
RGD:1591020
See related
EnsemblRapid:ENSRNOG00000019434 AllianceGenome:RGD:1591020
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable RNA binding activity and tRNA-specific adenosine deaminase activity. Predicted to be involved in tRNA processing. Orthologous to human ADAT1 (adenosine deaminase tRNA specific 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 16.8), Adrenal (RPKM 16.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Adat1 in Genome Data Viewer
Location:
19q12
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (56825153..56866136, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (39918083..39956886, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (44172496..44212147, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene carbohydrate sulfotransferase 5 Neighboring gene transmembrane protein 231 Neighboring gene GABA type A receptor associated protein like 2 Neighboring gene lysyl-tRNA synthetase 1 Neighboring gene TERF2 interacting protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification and characterization of a human tRNA-specific adenosine deaminase related to the ADAR family of pre-mRNA editing enzymes. Maas S, et al. Proc Natl Acad Sci U S A, 1999 Aug 3. PMID 10430867, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA-specific adenosine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA-specific adenosine deaminase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in tRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA processing ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tRNA-specific adenosine deaminase 1
NP_001103081.1
NP_001383775.1
XP_006255697.1
XP_006255698.1
XP_006255700.1
XP_008770757.2
XP_038953929.1
XP_038953931.1
XP_063134368.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109611.2 → NP_001103081.1  tRNA-specific adenosine deaminase 1 isoform 1

    See identical proteins and their annotated locations for NP_001103081.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    A0A8I6GI65, A6IZC1, D4ADL5
    Related
    ENSRNOP00000026309.3, ENSRNOT00000026309.7
    Conserved Domains (1) summary
    pfam02137
    Location:62 → 490
    A_deamin; Adenosine-deaminase (editase) domain

  2. NM_001396846.1 → NP_001383775.1  tRNA-specific adenosine deaminase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    A0A8I6GI65
    Related
    ENSRNOP00000080487.2, ENSRNOT00000110420.2
    Conserved Domains (1) summary
    pfam02137
    Location:62 → 451
    A_deamin; Adenosine-deaminase (editase) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    56825153..56866136 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008772535.4 → XP_008770757.2  tRNA-specific adenosine deaminase 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZQD8, A0A8I6GI65
    Related
    ENSRNOP00000108371.1, ENSRNOT00000122018.1

  2. XM_063278298.1 → XP_063134368.1  tRNA-specific adenosine deaminase 1 isoform X5

  3. XM_039098003.1 → XP_038953931.1  tRNA-specific adenosine deaminase 1 isoform X4

    Conserved Domains (1) summary
    cl02661
    Location:62 → 245
    A_deamin; Adenosine-deaminase (editase) domain

  4. XM_006255635.5 → XP_006255697.1  tRNA-specific adenosine deaminase 1 isoform X1

    See identical proteins and their annotated locations for XP_006255697.1

    UniProtKB/TrEMBL
    A0A8I6GI65, A6IZC1, D4ADL5
    Conserved Domains (1) summary
    pfam02137
    Location:62 → 490
    A_deamin; Adenosine-deaminase (editase) domain

  5. XM_006255636.5 → XP_006255698.1  tRNA-specific adenosine deaminase 1 isoform X1

    See identical proteins and their annotated locations for XP_006255698.1

    UniProtKB/TrEMBL
    A0A8I6GI65, A6IZC1, D4ADL5
    Conserved Domains (1) summary
    pfam02137
    Location:62 → 490
    A_deamin; Adenosine-deaminase (editase) domain

  6. XM_039098001.2 → XP_038953929.1  tRNA-specific adenosine deaminase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GI65, A6IZC1, D4ADL5
    Conserved Domains (1) summary
    pfam02137
    Location:62 → 490
    A_deamin; Adenosine-deaminase (editase) domain

  7. XM_006255638.3 → XP_006255700.1  tRNA-specific adenosine deaminase 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I6GI65
    Conserved Domains (1) summary
    pfam02137
    Location:1 → 428
    A_deamin; Adenosine-deaminase (editase) domain
Nucleotide Protein Strain
Heading Accession and Version

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