Cnn2 calponin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cnn2provided by RGD
Official Full Name: calponin 2provided by RGD
Primary source: RGD:1589807
See related: EnsemblRapid:ENSRNOG00000043044 AllianceGenome:RGD:1589807
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization. Predicted to act upstream of or within several processes, including cellular response to mechanical stimulus; negative regulation of macrophage migration; and negative regulation of phagocytosis. Predicted to be located in stress fiber. Predicted to be active in actin cytoskeleton. Orthologous to human CNN2 (calponin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 622.3), Thymus (RPKM 508.2) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (10363141..10370312, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (9712505..9719678, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (12782459..12787977)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH139166 (e-PCR)
- UniSTS:221252

RH127486 (e-PCR)
- UniSTS:210796

RH131872 (e-PCR)
- UniSTS:215155

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actomyosin structure organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of establishment of localization in cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hemopoiesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of macrophage migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of macrophage migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of phagocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of actin filament-based process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of leukocyte proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of mononuclear cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within wound healing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in stress fiber	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: calponin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399010.1 → NP_001385939.1 calponin-2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

Related

ENSRNOP00000063042.5, ENSRNOT00000065093.5

Conserved Domains (2) summary

pfam00402
Location:166 → 190

Calponin; Calponin family repeat

cd21283
Location:27 → 135

CH_CNN2; calponin homology (CH) domain found in calponin-2