U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Faxdc2 fatty acid hydroxylase domain containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 691221, updated on 10-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
Faxdc2provided by RGD
Official Full Name
fatty acid hydroxylase domain containing 2provided by RGD
Primary source
RGD:1586284
See related
EnsemblRapid:ENSRNOG00000027259 AllianceGenome:RGD:1586284
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable iron ion binding activity. Predicted to be involved in positive regulation of megakaryocyte differentiation and positive regulation of protein phosphorylation. Predicted to be located in cytoplasm. Orthologous to human FAXDC2 (fatty acid hydroxylase domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 241.5), Lung (RPKM 198.9) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Faxdc2 in Genome Data Viewer
Location:
10q22
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (42747323..42772156, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (42245808..42271679, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (43500825..43526376, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480691 Neighboring gene La ribonucleoprotein 1, translational regulator Neighboring gene ATP synthase membrane subunit K like 1 Neighboring gene uncharacterized LOC134480692 Neighboring gene transfer RNA serine (anticodon AGA) 43 Neighboring gene CCR4-NOT transcription complex, subunit 8

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Novel function of FAXDC2 in megakaryopoiesis. Jin Q, et al. Blood Cancer J, 2016 Sep 30. PMID 27689744, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of megakaryocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in sterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
fatty acid hydroxylase domain containing 2; fatty acid hydroxylase domain-containing protein 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001430287.1 → NP_001417216.1  fatty acid hydroxylase domain containing 2 isoform a

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

  2. NM_001430288.1 → NP_001417217.1  fatty acid hydroxylase domain containing 2 isoform a

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

  3. NM_001430289.1 → NP_001417218.1  fatty acid hydroxylase domain containing 2 isoform a

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

  4. NM_001430290.1 → NP_001417219.1  fatty acid hydroxylase domain containing 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

  5. NM_001430291.1 → NP_001417220.1  fatty acid hydroxylase domain containing 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

  6. NM_001430292.1 → NP_001417221.1  fatty acid hydroxylase domain containing 2 isoform c

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

  7. NM_001430293.1 → NP_001417222.1  fatty acid hydroxylase domain containing 2 isoform d

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

  8. NM_001430294.1 → NP_001417223.1  fatty acid hydroxylase domain containing 2 isoform e

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    42747323..42772156 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039087211.2 → XP_038943139.1  fatty acid hydroxylase domain-containing protein 2 isoform X4

    Conserved Domains (1) summary
    pfam04116
    Location:192 → 266
    FA_hydroxylase; Fatty acid hydroxylase superfamily

  2. XM_017597634.3 → XP_017453123.1  fatty acid hydroxylase domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    F1M8Z0
    Related
    ENSRNOP00000101741.1, ENSRNOT00000161793.1

  3. XM_039087209.2 → XP_038943137.1  fatty acid hydroxylase domain-containing protein 2 isoform X3

    Related
    ENSRNOP00000033145.7, ENSRNOT00000036481.7
    Conserved Domains (1) summary
    pfam04116
    Location:152 → 276
    FA_hydroxylase; Fatty acid hydroxylase superfamily

  4. XM_039087212.2 → XP_038943140.1  fatty acid hydroxylase domain-containing protein 2 isoform X5

    Conserved Domains (1) summary
    pfam04116
    Location:135 → 259
    FA_hydroxylase; Fatty acid hydroxylase superfamily

  5. XM_063270030.1 → XP_063126100.1  fatty acid hydroxylase domain-containing protein 2 isoform X3

  6. XM_039087213.2 → XP_038943141.1  fatty acid hydroxylase domain-containing protein 2 isoform X6

    Conserved Domains (1) summary
    pfam04116
    Location:76 → 200
    FA_hydroxylase; Fatty acid hydroxylase superfamily

  7. XM_039087208.2 → XP_038943136.1  fatty acid hydroxylase domain-containing protein 2 isoform X2

    Conserved Domains (1) summary
    pfam04116
    Location:246 → 354
    FA_hydroxylase; Fatty acid hydroxylase superfamily
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools