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Stk38l serine/threonine kinase 38 like [ Rattus norvegicus (Norway rat) ]

Gene ID: 691337, updated on 14-Nov-2024

Summary

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Official Symbol
Stk38lprovided by RGD
Official Full Name
serine/threonine kinase 38 likeprovided by RGD
Primary source
RGD:1564793
See related
EnsemblRapid:ENSRNOG00000001828 AllianceGenome:RGD:1564793
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1564793
Summary
Predicted to enable ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in postsynapse organization. Is active in glutamatergic synapse. Orthologous to human STK38L (serine/threonine kinase 38 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 85.4), Kidney (RPKM 73.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Stk38l in Genome Data Viewer
Location:
4q44
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (181346969..181423844)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (179616288..179693177)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (181027212..181089735)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene transmembrane 7 superfamily member 3 Neighboring gene mediator complex subunit 21 Neighboring gene basic helix-loop-helix ARNT like 2 Neighboring gene single-pass membrane protein with coiled-coil domains 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Nuclear Dbf2-related protein kinases (NDRs) in isolated cardiac myocytes and the myocardium: activation by cellular stresses and by phosphoprotein serine-/threonine-phosphatase inhibitors. Fuller SJ, et al. Cell Signal, 2008 Aug. PMID 18555663
  2. Neuronal functions of the novel serine/threonine kinase Ndr2. Stork O, et al. J Biol Chem, 2004 Oct 29. PMID 15308672
  3. Regulation of NDR2 protein kinase by multi-site phosphorylation and the S100B calcium-binding protein. Stegert MR, et al. J Biol Chem, 2004 May 28. PMID 15037617
  4. Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases. Devroe E, et al. J Biol Chem, 2004 Jun 4. PMID 15067004
  5. Chemical genetic identification of NDR1/2 kinase substrates AAK1 and Rabin8 Uncovers their roles in dendrite arborization and spine development. Ultanir SK, et al. Neuron, 2012 Mar 22. PMID 22445341, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in postsynapse organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in postsynapse organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cellular component organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase 38-like
NP_001076805.1
XP_038964321.1
XP_038964322.1
XP_063142795.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083336.3 → NP_001076805.1  serine/threonine-protein kinase 38-like

    See identical proteins and their annotated locations for NP_001076805.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A0G2JT94, A4GW50, B1H211, D4AA09
    Related
    ENSRNOP00000002502.6, ENSRNOT00000002502.9
    Conserved Domains (1) summary
    cd05627
    Location:87 → 452
    STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    181346969..181423844
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039108393.2 → XP_038964321.1  serine/threonine-protein kinase 38-like isoform X1

    UniProtKB/TrEMBL
    A0A0G2JT94, A4GW50, B1H211, D4AA09
    Conserved Domains (1) summary
    cd05627
    Location:87 → 452
    STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2

  2. XM_039108394.2 → XP_038964322.1  serine/threonine-protein kinase 38-like isoform X1

    UniProtKB/TrEMBL
    A0A0G2JT94, A4GW50, B1H211, D4AA09
    Conserved Domains (1) summary
    cd05627
    Location:87 → 452
    STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2

  3. XM_063286725.1 → XP_063142795.1  serine/threonine-protein kinase 38-like isoform X1

    UniProtKB/TrEMBL
    A4GW50, B1H211, D4AA09
    Related
    ENSRNOP00000109020.1, ENSRNOT00000140393.1
Nucleotide Protein Strain
Heading Accession and Version

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