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Shisa7 shisa family member 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 691429, updated on 2-Nov-2024

Summary

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Official Symbol
Shisa7provided by RGD
Official Full Name
shisa family member 7provided by RGD
Primary source
RGD:1583944
See related
EnsemblRapid:ENSRNOG00000016877 AllianceGenome:RGD:1583944
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GABA receptor binding activity and ionotropic glutamate receptor binding activity. Predicted to be involved in several processes, including gamma-aminobutyric acid receptor clustering; positive regulation of long-term synaptic potentiation; and regulation of signaling receptor activity. Predicted to be located in asymmetric, glutamatergic, excitatory synapse. Predicted to be active in glutamatergic synapse; postsynaptic density; and synaptic membrane. Orthologous to human SHISA7 (shisa family member 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 25.3), Testes (RPKM 6.3) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Shisa7 in Genome Data Viewer
Location:
1q12
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (78022680..78041748)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (68993900..69012943)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (72545413..72564513)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ATPase H+ transporting V0 subunit C, pseudogene 2 Neighboring gene isochorismatase domain containing 2b Neighboring gene uncharacterized LOC134482885 Neighboring gene ubiquitin-conjugating enzyme E2S

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Shisa7 is a GABA(A) receptor auxiliary subunit controlling benzodiazepine actions. Han W, et al. Science, 2019 Oct 11. PMID 31601770, Free PMC Article
  2. The AMPA receptor-associated protein Shisa7 regulates hippocampal synaptic function and contextual memory. Schmitz LJM, et al. Elife, 2017 Dec 4. PMID 29199957, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GABA receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GABA receptor binding ISO
Inferred from Sequence Orthology
more info
  
NOT enables ionotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables ionotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in gamma-aminobutyric acid receptor clustering IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in gamma-aminobutyric acid receptor clustering ISO
Inferred from Sequence Orthology
more info
  
involved_in gamma-aminobutyric acid signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in gamma-aminobutyric acid signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in memory ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in regulation of AMPA glutamate receptor clustering ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of AMPA glutamate receptor clustering ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in regulation of AMPA receptor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of GABA-A receptor activity IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of GABA-A receptor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynaptic neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of postsynaptic neurotransmitter receptor activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
NOT part_of AMPA glutamate receptor complex ISO
Inferred from Sequence Orthology
more info
  
NOT located_in asymmetric, glutamatergic, excitatory synapse ISO
Inferred from Sequence Orthology
more info
  
located_in asymmetric, glutamatergic, excitatory synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in dendritic spine membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT located_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic specialization membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein shisa-7
Names
shisa homolog 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145175.1 → NP_001138647.1  protein shisa-7 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    D3ZPJ0
    Related
    ENSRNOP00000022698.3, ENSRNOT00000022698.5
    Conserved Domains (1) summary
    pfam13908
    Location:83 → 142
    Shisa; Wnt and FGF inhibitory regulator

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    78022680..78041748
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063274859.1 → XP_063130929.1  protein shisa-7 isoform X2

    Related
    ENSRNOP00000108986.1, ENSRNOT00000161994.1

  2. XM_017589753.3 → XP_017445242.1  protein shisa-7 isoform X1

    UniProtKB/TrEMBL
    D3ZPJ0
    Conserved Domains (1) summary
    pfam13908
    Location:83 → 142
    Shisa; Wnt and FGF inhibitory regulator

  3. XM_039091565.2 → XP_038947493.1  protein shisa-7 isoform X3

    UniProtKB/TrEMBL
    A0A8I6ANL3
    Related
    ENSRNOP00000094674.1, ENSRNOT00000114646.2
    Conserved Domains (1) summary
    pfam13908
    Location:83 → 142
    Shisa; Wnt and FGF inhibitory regulator

  4. XM_039091559.2 → XP_038947487.1  protein shisa-7 isoform X1

    UniProtKB/TrEMBL
    D3ZPJ0
    Conserved Domains (1) summary
    pfam13908
    Location:83 → 142
    Shisa; Wnt and FGF inhibitory regulator

  5. XM_017589754.3 → XP_017445243.1  protein shisa-7 isoform X1

    UniProtKB/TrEMBL
    D3ZPJ0
    Conserved Domains (1) summary
    pfam13908
    Location:83 → 142
    Shisa; Wnt and FGF inhibitory regulator

  6. XM_017589755.3 → XP_017445244.1  protein shisa-7 isoform X1

    UniProtKB/TrEMBL
    D3ZPJ0
    Conserved Domains (1) summary
    pfam13908
    Location:83 → 142
    Shisa; Wnt and FGF inhibitory regulator

  7. XM_063274863.1 → XP_063130933.1  protein shisa-7 isoform X4

Nucleotide Protein Strain
Heading Accession and Version

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