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Erp27 endoplasmic reticulum protein 27 [ Mus musculus (house mouse) ]

Gene ID: 69187, updated on 2-Nov-2024

Summary

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Official Symbol
Erp27provided by MGI
Official Full Name
endoplasmic reticulum protein 27provided by MGI
Primary source
MGI:MGI:1916437
See related
Ensembl:ENSMUSG00000030219 AllianceGenome:MGI:1916437
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810033M07Rik; 1810047B09Rik
Summary
Predicted to be involved in protein folding and response to endoplasmic reticulum stress. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum. Is expressed in diencephalon lateral wall mantle layer and midbrain mantle layer. Orthologous to human ERP27 (endoplasmic reticulum protein 27). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in spleen adult (RPKM 3.3), small intestine adult (RPKM 2.9) and 4 other tissues See more
Orthologs
human all
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Genomic context

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See Erp27 in Genome Data Viewer
Location:
6 G1; 6 66.72 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (136884312..136899465, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (136907314..136922461, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ADP-ribosyltransferase 4 Neighboring gene matrix Gla protein Neighboring gene STARR-seq mESC enhancer starr_17614 Neighboring gene Rho, GDP dissociation inhibitor beta Neighboring gene STARR-positive B cell enhancer ABC_E3690 Neighboring gene phosphodiesterase 6H, cGMP-specific, cone, gamma

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC129514, MGC129515

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NOT enables protein disulfide isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to endoplasmic reticulum stress IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to unfolded protein IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
endoplasmic reticulum resident protein 27
Names
ER protein 27
endoplasmic reticulum resident protein ERp27
inactive protein disulfide-isomerase 27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417693.1 → NP_001404622.1  endoplasmic reticulum resident protein 27 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122804, AC125341
    UniProtKB/TrEMBL
    Q9D8Q5
    Related
    ENSMUST00000162243.8

  2. NM_026983.2 → NP_081259.1  endoplasmic reticulum resident protein 27 isoform 1 precursor

    See identical proteins and their annotated locations for NP_081259.1

    Status: VALIDATED

    Source sequence(s)
    AK007684
    Consensus CDS
    CCDS20660.1
    UniProtKB/Swiss-Prot
    Q3SX97, Q9D8U3
    Related
    ENSMUSP00000032343.7, ENSMUST00000032343.7
    Conserved Domains (1) summary
    pfam13848
    Location:64 → 250
    Thioredoxin_6; Thioredoxin-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    136884312..136899465 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506554.3 → XP_006506617.1  endoplasmic reticulum resident protein 27 isoform X1

    See identical proteins and their annotated locations for XP_006506617.1

    Conserved Domains (1) summary
    pfam13848
    Location:1 → 174
    Thioredoxin_6; Thioredoxin-like domain

  2. XM_006506555.4 → XP_006506618.1  endoplasmic reticulum resident protein 27 isoform X1

    See identical proteins and their annotated locations for XP_006506618.1

    Conserved Domains (1) summary
    pfam13848
    Location:1 → 174
    Thioredoxin_6; Thioredoxin-like domain

  3. XM_036152285.1 → XP_036008178.1  endoplasmic reticulum resident protein 27 isoform X1

    Conserved Domains (1) summary
    pfam13848
    Location:1 → 174
    Thioredoxin_6; Thioredoxin-like domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D8U3.1 GenPept UniProtKB/Swiss-Prot:Q9D8U3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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