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Atp8a2 ATPase phospholipid transporting 8A2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 691889, updated on 17-Aug-2024

Summary

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Official Symbol
Atp8a2provided by RGD
Official Full Name
ATPase phospholipid transporting 8A2provided by RGD
Primary source
RGD:1594597
See related
EnsemblRapid:ENSRNOG00000008053 AllianceGenome:RGD:1594597
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATPase-coupled intramembrane lipid transporter activity. Acts upstream of or within neuron projection development. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in cerebellar ataxia, mental retardation and dysequlibrium syndrome. Orthologous to human ATP8A2 (ATPase phospholipid transporting 8A2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 50.5), Testes (RPKM 50.3) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Atp8a2 in Genome Data Viewer
Location:
15p12
Exon count:
49
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (37993507..38526408, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (33817309..34350193, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (39955689..40488737, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S9, pseudogene 9 Neighboring gene eukaryotic translation initiation factor 4B, pseudogene 1 Neighboring gene shisa family member 2 Neighboring gene uncharacterized LOC134481976 Neighboring gene ETS-related transcription factor Elf-2 pseudogene Neighboring gene uncharacterized LOC103693635 Neighboring gene nucleoporin 58 Neighboring gene myotubularin related protein 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phospholipid flippase ATP8A2 is required for normal visual and auditory function and photoreceptor and spiral ganglion cell survival. Coleman JA, et al. J Cell Sci, 2014 Mar 1. PMID 24413176, Free PMC Article
  2. Mutations in a P-type ATPase gene cause axonal degeneration. Zhu X, et al. PLoS Genet, 2012. PMID 22912588, Free PMC Article
  3. P4-ATPase ATP8A2 acts in synergy with CDC50A to enhance neurite outgrowth. Xu Q, et al. FEBS Lett, 2012 Jun 21. PMID 22641037
  4. Genetic and age related models of neurodegeneration in mice: dystrophic axons. Bronson RT, et al. J Neurogenet, 1992 May. PMID 1634998
  5. Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4-ATPases. van der Velden LM, et al. J Biol Chem, 2010 Dec 17. PMID 20947505, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled intramembrane lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aminophospholipid flippase activity ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in aminophospholipid translocation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within axonogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in detection of light stimulus involved in visual perception ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within determination of adult lifespan ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within eating behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in inner ear morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within involuntary skeletal muscle contraction ISO
Inferred from Sequence Orthology
more info
  
involved_in neurofilament cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuromuscular process controlling posture ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuron development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of phospholipid translocation ISO
Inferred from Sequence Orthology
more info
  
involved_in response to auditory stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in retina layer formation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within skin development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of phospholipid-translocating ATPase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phospholipid-transporting ATPase IB
Names
ATPase, aminophospholipid transporter, class I, type 8A, member 2
NP_001414379.1
XP_003751540.1
XP_038949921.1
XP_038949922.1
XP_038949924.1
XP_038949925.1
XP_038949926.1
XP_038949927.1
XP_038949928.1
XP_038949929.1
XP_038949930.1
XP_038949931.1
XP_038949932.1
XP_038949933.1
XP_063130743.1
XP_063130744.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427450.1 → NP_001414379.1  phospholipid-transporting ATPase IB

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A0A8I5ZQP3, A0A8I6AGF0
    Related
    ENSRNOP00000095034.2, ENSRNOT00000116305.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    37993507..38526408 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039093999.2 → XP_038949927.1  phospholipid-transporting ATPase IB isoform X5

    UniProtKB/TrEMBL
    A0A8I6AGF0
    Conserved Domains (1) summary
    TIGR01652
    Location:28 → 1078
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

  2. XM_039093996.2 → XP_038949924.1  phospholipid-transporting ATPase IB isoform X5

    UniProtKB/TrEMBL
    A0A8I6AGF0
    Conserved Domains (1) summary
    TIGR01652
    Location:28 → 1078
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

  3. XM_039093997.2 → XP_038949925.1  phospholipid-transporting ATPase IB isoform X5

    UniProtKB/TrEMBL
    A0A8I6AGF0
    Conserved Domains (1) summary
    TIGR01652
    Location:28 → 1078
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

  4. XM_039094002.2 → XP_038949930.1  phospholipid-transporting ATPase IB isoform X5

    UniProtKB/TrEMBL
    A0A8I6AGF0
    Conserved Domains (1) summary
    TIGR01652
    Location:28 → 1078
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

  5. XM_039094003.1 → XP_038949931.1  phospholipid-transporting ATPase IB isoform X6

    UniProtKB/TrEMBL
    A0A8I6AGF0
    Conserved Domains (1) summary
    TIGR01652
    Location:68 → 1043
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

  6. XM_003751492.5 → XP_003751540.1  phospholipid-transporting ATPase IB isoform X3

    UniProtKB/TrEMBL
    A0A8I6AGF0
    Related
    ENSRNOP00000080718.2, ENSRNOT00000099280.2
    Conserved Domains (6) summary
    TIGR01652
    Location:68 → 1106
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:125 → 342
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:506 → 604
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:57 → 119
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:848 → 1099
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:816 → 845
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  7. XM_039093993.1 → XP_038949921.1  phospholipid-transporting ATPase IB isoform X1

    UniProtKB/TrEMBL
    A0A8I6A3Z6, A0A8I6AGF0
    Conserved Domains (1) summary
    TIGR01652
    Location:68 → 1118
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

  8. XM_039093998.1 → XP_038949926.1  phospholipid-transporting ATPase IB isoform X5

    UniProtKB/TrEMBL
    A0A8I6AGF0
    Conserved Domains (1) summary
    TIGR01652
    Location:28 → 1078
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

  9. XM_039093994.2 → XP_038949922.1  phospholipid-transporting ATPase IB isoform X2

    UniProtKB/TrEMBL
    A0A8I6GLF5
    Conserved Domains (1) summary
    TIGR01652
    Location:67 → 1117
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

  10. XM_039094000.2 → XP_038949928.1  phospholipid-transporting ATPase IB isoform X5

    UniProtKB/TrEMBL
    A0A8I6AGF0
    Conserved Domains (1) summary
    TIGR01652
    Location:28 → 1078
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

  11. XM_063274673.1 → XP_063130743.1  phospholipid-transporting ATPase IB isoform X4

    UniProtKB/TrEMBL
    A0A8I6AGF0

  12. XM_039094001.2 → XP_038949929.1  phospholipid-transporting ATPase IB isoform X5

    UniProtKB/TrEMBL
    A0A8I6AGF0
    Conserved Domains (1) summary
    TIGR01652
    Location:28 → 1078
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

  13. XM_063274674.1 → XP_063130744.1  phospholipid-transporting ATPase IB isoform X7

    UniProtKB/TrEMBL
    A0A8I6GLF5

  14. XM_039094004.2 → XP_038949932.1  phospholipid-transporting ATPase IB isoform X8

    Conserved Domains (1) summary
    TIGR01652
    Location:68 → 806
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

  15. XM_039094005.2 → XP_038949933.1  phospholipid-transporting ATPase IB isoform X9

    Conserved Domains (1) summary
    TIGR01652
    Location:68 → 760
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
Nucleotide Protein Strain
Heading Accession and Version

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